C57BL/6JCya-Lrit2em1/Cya
Common Name:
Lrit2-KO
Product ID:
S-KO-19016
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lrit2-KO
Strain ID
KOCMP-239038-Lrit2-B6J-VB
Gene Name
Product ID
S-KO-19016
Gene Alias
A930010E21Rik; Lrrc22
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
14
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lrit2em1/Cya mice (Catalog S-KO-19016) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000057176
NCBI RefSeq
NM_173418
Target Region
Exon 1~2
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
Lrit2 is a gene whose function was previously unknown in mouse visual functions. Through integrated analysis, it was found to be potentially involved in eye-related functions, but specific aliases, associated pathways and its overall biological importance need further in-depth study. Animal models like zebrafish can be valuable in understanding its function [1].
An integrated transcriptome-phenome analysis in mice predicted over 50 genes involved in visual functions, with Lrit2 among them. Gene-specific morpholinos were introduced into zebrafish to target the ortholog of Lrit2. Quantitative assessments of developing eye phenotypes confirmed its predicted eye-related function [1].
In conclusion, Lrit2 likely plays a role in eye-related functions as revealed through model-based research, with zebrafish models contributing to understanding its role in visual function-related biological processes. This study provides a basis for further exploration of the role of Lrit2 in eye-related diseases [1].
References：
1. Chiang, Chia-Yin, Ching, Yung-Hao, Chang, Ting-Yan, Lin, Ming-Der, Liao, Ben-Yang. 2019. Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome. In Computational and structural biotechnology journal, 18, 73-82. doi:10.1016/j.csbj.2019.12.009. https://pubmed.ncbi.nlm.nih.gov/31934309/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen