C57BL/6JCya-Lrit2em1/Cya
Common Name
Lrit2-KO
Product ID
S-KO-19016
Backgroud
C57BL/6JCya
Strain ID
KOCMP-239038-Lrit2-B6J-VB
When using this mouse strain in a publication, please cite “Lrit2-KO Mouse (Catalog S-KO-19016) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Lrit2-KO
Strain ID
KOCMP-239038-Lrit2-B6J-VB
Gene Name
Product ID
S-KO-19016
Gene Alias
A930010E21Rik, Lrrc22
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000057176
NCBI RefSeq
NM_173418
Target Region
Exon 1~2
Size of Effective Region
~2.3 kb
Overview of Gene Research
Lrit2 is a gene whose function was previously unknown in mouse visual functions. Through integrated analysis, it was found to be potentially involved in eye-related functions, but specific aliases, associated pathways and its overall biological importance need further in-depth study. Animal models like zebrafish can be valuable in understanding its function [1].
An integrated transcriptome-phenome analysis in mice predicted over 50 genes involved in visual functions, with Lrit2 among them. Gene-specific morpholinos were introduced into zebrafish to target the ortholog of Lrit2. Quantitative assessments of developing eye phenotypes confirmed its predicted eye-related function [1].
In conclusion, Lrit2 likely plays a role in eye-related functions as revealed through model-based research, with zebrafish models contributing to understanding its role in visual function-related biological processes. This study provides a basis for further exploration of the role of Lrit2 in eye-related diseases [1].
References：
1. Chiang, Chia-Yin, Ching, Yung-Hao, Chang, Ting-Yan, Lin, Ming-Der, Liao, Ben-Yang. 2019. Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome. In Computational and structural biotechnology journal, 18, 73-82. doi:10.1016/j.csbj.2019.12.009. https://pubmed.ncbi.nlm.nih.gov/31934309/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.