C57BL/6JCya-Slc35f2em1/Cya
Common Name:
Slc35f2-KO
Product ID:
S-KO-19075
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Slc35f2-KO
Strain ID
KOCMP-72022-Slc35f2-B6J-VB
Gene Name
Product ID
S-KO-19075
Gene Alias
1500009K05Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc35f2em1/Cya mice (Catalog S-KO-19075) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000048670
NCBI RefSeq
NM_028060
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Slc35f2, a member of the solute carrier family, is a membrane-bound carrier protein. It is associated with multiple physiological functions, and its dysregulation is linked to cancer-related pathways [2,4]. It has been implicated in processes such as cell growth, migration, and invasion, making it of high biological importance in cancer research.
Knockdown of Slc35f2 in bladder cancer cells inhibits their proliferation, migration, and invasion, and promotes apoptosis. Nude mouse tumor formation experiments also showed that Slc35f2 knockdown significantly reduced tumorigenesis, indicating its role in bladder cancer progression [3]. In pancreatic cancer cells, Slc35f2 inhibits ferroptosis by facilitating TRIM59-mediated p53 degradation through a SLC35F2-SYVN1-TRIM59 axis, highlighting its significance in pancreatic cancer-related ferroptosis regulation [1].
In conclusion, Slc35f2 plays a crucial role in cancer-related biological processes. The findings from loss-of-function experiments, such as knockdown in bladder and pancreatic cancer cells, have revealed its importance in cancer progression and ferroptosis regulation, suggesting it could be a potential therapeutic target for treating bladder and pancreatic cancers.
References：
1. Che, Ben, Du, Yunyan, Yuan, Rongfa, Wang, Kai, Chen, Leifeng. 2023. SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53. In Oncogene, 42, 3260-3273. doi:10.1038/s41388-023-02843-y. https://pubmed.ncbi.nlm.nih.gov/37740007/
2. Colaco, Jencia Carminha, Chandrasekaran, Arun Pandian, Karapurkar, Janardhan Keshav, Kim, Kye-Seong, Ramakrishna, Suresh. 2023. βTrCP1 promotes SLC35F2 protein ubiquitination and inhibits cancer progression in HeLa cells. In Biochemical and biophysical research communications, 682, 27-38. doi:10.1016/j.bbrc.2023.09.095. https://pubmed.ncbi.nlm.nih.gov/37801987/
3. Chen, Mei, Gao, Xin, Huang, Denggao, Cao, Hui, Zhang, Shufang. 2019. Knockdown of SLC35F2 Inhibits the Proliferation and Metastasis of Bladder Cancer Cells. In OncoTargets and therapy, 12, 10771-10786. doi:10.2147/OTT.S229332. https://pubmed.ncbi.nlm.nih.gov/31849485/
4. Colaco, Jencia Carminha, Chandrasekaran, Arun Pandian, Karapurkar, Janardhan Keshav, Kim, Kye-Seong, Ramakrishna, Suresh. 2023. E3 ubiquitin ligase APC/CCdh1 regulates SLC35F2 protein turnover and inhibits cancer progression in HeLa cells. In Biochimica et biophysica acta. General subjects, 1867, 130454. doi:10.1016/j.bbagen.2023.130454. https://pubmed.ncbi.nlm.nih.gov/37689217/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen