C57BL/6JCya-Grik2em1/Cya
Common Name:
Grik2-KO
Product ID:
S-KO-19087
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Grik2-KO
Strain ID
KOCMP-14806-Grik2-B6J-VB
Gene Name
Product ID
S-KO-19087
Gene Alias
C130030K03Rik; GluK2; Glur-6; Glur6; Glurbeta2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Grik2em1/Cya mice (Catalog S-KO-19087) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000218823
NCBI RefSeq
NM_001111268
Target Region
Exon 5
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
GRIK2, also known as GluR6, encodes an ionotropic glutamate receptor kainate 2. Glutamate receptors are crucial for neurotransmission in the central nervous system, and GRIK2-related kainate receptors play diverse roles in this system [5].
In cancer research, GRIK2-derived antigenic peptides are specifically expressed by bladder cancer stem-like cells (CSCs/CICs), making GRIK2 a potential target for bladder CSC/CIC-targeting immunotherapy [1]. In urothelial carcinoma, GRIK2 has a role in maintaining CSCs/CICs, and higher GRIK2 expression is associated with poorer prognosis [3].
In epilepsy, certain single-nucleotide polymorphisms (SNPs) in GRIK2, such as rs4840200-T and rs3213607-A, and the interaction between rs4840200 and rs9390754, are related to an increased risk of epilepsy in Chinese children [2]. Also, in bipolar manic patients, the rs2227283 polymorphism of GRIK2 is related to aggressive behaviors, with the A/A genotype and A allele increasing the risk [4].
In conclusion, GRIK2 is an important gene encoding a kainate receptor subunit with a role in neurotransmission. Research on GRIK2 using genetic models has revealed its significance in various disease areas, including cancer, epilepsy, and bipolar mania-related aggressive behaviors. These findings provide potential directions for disease-targeted therapies and further understanding of the underlying molecular mechanisms.
References：
1. Miyata, Haruka, Hirohashi, Yoshihiko, Yamada, Shuhei, Shinohara, Nobuo, Torigoe, Toshihiko. 2021. GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy. In Cancer immunology, immunotherapy : CII, 71, 795-806. doi:10.1007/s00262-021-03025-z. https://pubmed.ncbi.nlm.nih.gov/34405274/
2. Xiong, Shunjun, Wang, Yanjun, Li, Huijuan, Zhang, Xiaofang. 2019. Interaction among GRIK2 gene on epilepsy susceptibility in Chinese children. In Acta neurologica Scandinavica, 139, 540-545. doi:10.1111/ane.13089. https://pubmed.ncbi.nlm.nih.gov/30908586/
3. Inoue, Ryuta, Hirohashi, Yoshihiko, Kitamura, Hiroshi, Masumori, Naoya, Torigoe, Toshihiko. . GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis. In Oncotarget, 8, 28826-28839. doi:10.18632/oncotarget.16259. https://pubmed.ncbi.nlm.nih.gov/28418868/
4. Ma, Haibo, Xun, Guanglei, Zhang, Renyun, Yang, Xiaohua, Cao, Yu. 2019. Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population. In Brain and behavior, 9, e01449. doi:10.1002/brb3.1449. https://pubmed.ncbi.nlm.nih.gov/31631587/
5. Stolz, Jacob R, Foote, Kendall M, Veenstra-Knol, Hermine E, Carvill, Gemma L, Swanson, Geoffrey T. 2021. Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. In American journal of human genetics, 108, 1692-1709. doi:10.1016/j.ajhg.2021.07.007. https://pubmed.ncbi.nlm.nih.gov/34375587/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen