C57BL/6JCya-Grik2em1/Cya
Common Name:
Grik2-KO
Product ID:
S-KO-19087
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Grik2-KO
Strain ID
KOCMP-14806-Grik2-B6J-VB
Gene Name
Product ID
S-KO-19087
Gene Alias
C130030K03Rik; GluK2; Glur-6; Glur6; Glurbeta2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Grik2em1/Cya mice (Catalog S-KO-19087) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000218823
NCBI RefSeq
NM_001111268
Target Region
Exon 5
Size of Effective Region
~1.5 kb
Overview of Gene Research
GRIK2, also known as GluR6, encodes an ionotropic glutamate receptor kainate 2. Glutamate receptors are crucial for neurotransmission in the central nervous system, and GRIK2-related kainate receptors play diverse roles in this system [5].
In cancer research, GRIK2-derived antigenic peptides are specifically expressed by bladder cancer stem-like cells (CSCs/CICs), making GRIK2 a potential target for bladder CSC/CIC-targeting immunotherapy [1]. In urothelial carcinoma, GRIK2 has a role in maintaining CSCs/CICs, and higher GRIK2 expression is associated with poorer prognosis [3].
In epilepsy, certain single-nucleotide polymorphisms (SNPs) in GRIK2, such as rs4840200-T and rs3213607-A, and the interaction between rs4840200 and rs9390754, are related to an increased risk of epilepsy in Chinese children [2]. Also, in bipolar manic patients, the rs2227283 polymorphism of GRIK2 is related to aggressive behaviors, with the A/A genotype and A allele increasing the risk [4].
In conclusion, GRIK2 is an important gene encoding a kainate receptor subunit with a role in neurotransmission. Research on GRIK2 using genetic models has revealed its significance in various disease areas, including cancer, epilepsy, and bipolar mania-related aggressive behaviors. These findings provide potential directions for disease-targeted therapies and further understanding of the underlying molecular mechanisms.
References：
1. Miyata, Haruka, Hirohashi, Yoshihiko, Yamada, Shuhei, Shinohara, Nobuo, Torigoe, Toshihiko. 2021. GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy. In Cancer immunology, immunotherapy : CII, 71, 795-806. doi:10.1007/s00262-021-03025-z. https://pubmed.ncbi.nlm.nih.gov/34405274/
2. Xiong, Shunjun, Wang, Yanjun, Li, Huijuan, Zhang, Xiaofang. 2019. Interaction among GRIK2 gene on epilepsy susceptibility in Chinese children. In Acta neurologica Scandinavica, 139, 540-545. doi:10.1111/ane.13089. https://pubmed.ncbi.nlm.nih.gov/30908586/
3. Inoue, Ryuta, Hirohashi, Yoshihiko, Kitamura, Hiroshi, Masumori, Naoya, Torigoe, Toshihiko. . GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis. In Oncotarget, 8, 28826-28839. doi:10.18632/oncotarget.16259. https://pubmed.ncbi.nlm.nih.gov/28418868/
4. Ma, Haibo, Xun, Guanglei, Zhang, Renyun, Yang, Xiaohua, Cao, Yu. 2019. Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population. In Brain and behavior, 9, e01449. doi:10.1002/brb3.1449. https://pubmed.ncbi.nlm.nih.gov/31631587/
5. Stolz, Jacob R, Foote, Kendall M, Veenstra-Knol, Hermine E, Carvill, Gemma L, Swanson, Geoffrey T. 2021. Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. In American journal of human genetics, 108, 1692-1709. doi:10.1016/j.ajhg.2021.07.007. https://pubmed.ncbi.nlm.nih.gov/34375587/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen