C57BL/6JCya-Lix1lem1/Cya
Common Name:
Lix1l-KO
Product ID:
S-KO-19130
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Lix1l-KO
Strain ID
KOCMP-280411-Lix1l-B6J-VB
Gene Name
Product ID
S-KO-19130
Gene Alias
D130027M04Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lix1lem1/Cya mice (Catalog S-KO-19130) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000062058
NCBI RefSeq
NM_001163170
Target Region
Exon 2
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Lix1l, also known as Limb expression 1-like protein, is involved in post-transcriptional gene regulation [1,2,4]. It has been associated with multiple biological pathways and is of significance in various disease conditions. Genetic models, such as gene knockout (KO) mouse models, have been crucial in studying its functions.
Lix1l deficiency attenuated cholestatic liver injury in BDL and Mdr2-/-mice, indicating that Lix1l promotes cholestatic liver injury by regulating bile acid metabolism [1]. In metabolic dysfunction-associated steatohepatitis (MASH) and associated hepatocellular carcinoma (HCC), Lix1l deletion inhibited hepatic lipid accumulation, inflammation, fibrosis, and adipocyte differentiation, alleviating MASH and associated HCC progression in mice [2]. Also, Lix1l deficiency in vivo significantly attenuated liver cancer initiation in mice [3].
In conclusion, Lix1l plays important roles in cholestatic liver injury, MASH-HCC progression, and liver cancer development as revealed through KO mouse models. Understanding Lix1l functions can potentially provide new therapeutic targets for these diseases.
References：
1. Li, Jie, Zhu, Xiaoyun, Zhang, Meihui, Kong, Lingyi, Zhang, Hao. 2021. Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism. In Journal of hepatology, 75, 400-413. doi:10.1016/j.jhep.2021.02.035. https://pubmed.ncbi.nlm.nih.gov/33746084/
2. Leng, Yingrong, Zhang, Yanqiu, Cheng, Yang, Kong, Lingyi, Zhang, Hao. 2024. LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36. In Pharmacological research, 211, 107567. doi:10.1016/j.phrs.2024.107567. https://pubmed.ncbi.nlm.nih.gov/39725340/
3. Zou, Jie, Zhu, Xiaoyun, Xiang, Dejuan, Kong, Lingyi, Zhang, Hao. 2021. LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase. In Acta pharmaceutica Sinica. B, 11, 1578-1591. doi:10.1016/j.apsb.2021.02.005. https://pubmed.ncbi.nlm.nih.gov/34221869/
4. Li, Minglei, Zhang, Jiaxi, Meng, Xue, Shen, Haitao, Xing, Lingxiao. 2022. Limb expression 1-like protein promotes epithelial-mesenchymal transition and epidermal growth factor receptor-tyrosine kinase inhibitor resistance via nucleolin-mediated ribosomal RNA synthesis in non-small cell lung cancer. In Cancer science, 114, 1740-1756. doi:10.1111/cas.15687. https://pubmed.ncbi.nlm.nih.gov/36478492/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen