C57BL/6JCya-Nudt17em1/Cya
Common Name:
Nudt17-KO
Product ID:
S-KO-19226
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Nudt17-KO
Strain ID
KOCMP-78373-Nudt17-B6J-VB
Gene Name
Product ID
S-KO-19226
Gene Alias
2410015C20Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Nudt17em1/Cya mice (Catalog S-KO-19226) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029742
NCBI RefSeq
NM_001162925
Target Region
Exon 1~6
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Nudt17, a member of the Nudix hydrolase family, has been shown to possess mRNA decapping activity in vitro, contributing to gene expression regulation and mRNA decay [2]. It may also be involved in pathways related to inositol pyrophosphate catabolism, which impacts plant growth and development [5]. Understanding Nudt17's function through genetic models could provide insights into its biological importance.
In humans, Nudt17 gene polymorphisms have been associated with various disease risks. In a Chinese Han population, specific single nucleotide polymorphisms (SNPs) in Nudt17 were associated with a decreased breast cancer risk, with the rs9286836 G allele and rs2004659 G allele carriers having reduced risks [1]. Additionally, rs9286836 (Nudt17) on chromosome 1 showed a significant association with male gout in a genome-wide association study [3]. In clozapine-related neutropaenia, Nudt17 was identified as a gene whose expression may be causally related to the lowest absolute neutrophil count during clozapine treatment [4]. In clear cell renal cell carcinoma, low Nudt17 expression was associated with poorer overall survival rates, indicating its potential prognostic value [6].
In summary, Nudt17 plays a role in mRNA decapping and is associated with various human diseases such as breast cancer, gout, clozapine-related neutropaenia, and clear cell renal cell carcinoma. The study of Nudt17 through genetic models, like the analysis of its polymorphisms, provides valuable insights into its functions and disease associations, which could potentially contribute to disease prevention and treatment strategies.
References:
1. Han, Junhui, Liang, Jing, Zhou, Wenqian, Zhang, Man, Jin, Tianbo. 2024. Association between NUDT17 polymorphisms and breast cancer risk. In Expert review of molecular diagnostics, 24, 459-466. doi:10.1080/14737159.2024.2353700. https://pubmed.ncbi.nlm.nih.gov/38756100/
2. Song, Man-Gen, Bail, Sophie, Kiledjian, Megerditch. 2013. Multiple Nudix family proteins possess mRNA decapping activity. In RNA (New York, N.Y.), 19, 390-9. doi:10.1261/rna.037309.112. https://pubmed.ncbi.nlm.nih.gov/23353937/
3. Chang, Ya-Sian, Lin, Chien-Yu, Liu, Ting-Yuan, Chang, Jan-Gowth, Chang, Shun-Jen. 2022. Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study. In Arthritis research & therapy, 24, 229. doi:10.1186/s13075-022-02917-4. https://pubmed.ncbi.nlm.nih.gov/36221101/
4. Li, Jiqing, Tang, Fang, Si, Shucheng, Wang, Bojie, Xue, Fuzhong. 2021. Integration analysis of GWAS and expression quantitative trait loci to identify candidate genes and pathways for clozapine-related neutropaenia. In British journal of clinical pharmacology, 88, 1904-1912. doi:10.1111/bcp.15043. https://pubmed.ncbi.nlm.nih.gov/34409637/
5. Laurent, Florian, Bartsch, Simon M, Shukla, Anuj, Fiedler, Dorothea, Hothorn, Michael. 2024. Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. In PLoS genetics, 20, e1011468. doi:10.1371/journal.pgen.1011468. https://pubmed.ncbi.nlm.nih.gov/39531477/
6. Wang, Yue, Wan, Fangning, Chang, Kun, Dai, Bo, Ye, Dingwei. 2017. NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma. In Oncology letters, 14, 6121-6128. doi:10.3892/ol.2017.6997. https://pubmed.ncbi.nlm.nih.gov/29113256/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen