C57BL/6JCya-Ergic3em1/Cya
Common Name:
Ergic3-KO
Product ID:
S-KO-19260
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ergic3-KO
Strain ID
KOCMP-66366-Ergic3-B6J-VB
Gene Name
Product ID
S-KO-19260
Gene Alias
2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84; Sdbcag84
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ergic3em1/Cya mice (Catalog S-KO-19260) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000088650
NCBI RefSeq
NM_001356413
Target Region
Exon 5
Size of Effective Region
~0.4 kb
Detailed Document
Overview of Gene Research
Ergic3, also known as endoplasmic reticulum-Golgi intermediate compartment 3, is a type II transmembrane protein located in the endoplasmic reticulum and Golgi body. It is involved in the ER-to-Golgi transport, especially for gap junction proteins, and may participate in protein kinase-coupled receptors mediated signal transduction pathways [2,3]. Its abnormal expression is related to cancer development, making it a potential biomarker and therapeutic target.
Knockdown of Ergic3 in lung cancer cell lines and in a murine model of lung cancer led to endoplasmic reticulum stress-induced autophagic cell death and suppression of cell growth and tumorigenesis [1,4]. In hepatocellular carcinoma cells, Ergic3 knockdown affected the expression of genes involved in vesicular transport, growth factors, and immune-related pathways [3].
In conclusion, Ergic3 is crucial for the ER-to-Golgi transport of specific proteins. Studies with Ergic3 knockdown models have revealed its significant role in cancer, especially in lung and liver cancers, suggesting that targeting Ergic3 could be a potential strategy for cancer treatment.
References：
1. Zhao, Qiurong, Wu, Mingsong, Zheng, Xiang, Li, Xueying, Chen, Jindong. . ERGIC3 Silencing Additively Enhances the Growth Inhibition of BFA on Lung Adenocarcinoma Cells. In Current cancer drug targets, 20, 67-75. doi:10.2174/1568009619666190917145906. https://pubmed.ncbi.nlm.nih.gov/31530266/
2. Guan, Liying, Yang, Yongzhi, Liang, Jingjing, Wang, Yingchun, Ding, Mei. 2022. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. In Traffic (Copenhagen, Denmark), 23, 140-157. doi:10.1111/tra.12830. https://pubmed.ncbi.nlm.nih.gov/34994051/
3. Liu, Mengyuan, Zhao, Qiurong, Zheng, Xiang, Li, Xueying, Wu, Mingsong. 2022. Transcriptome changes in ERGIC3-knockdown hepatocellular carcinoma cells: ERGIC3 is a novel immune function related gene. In PeerJ, 10, e13369. doi:10.7717/peerj.13369. https://pubmed.ncbi.nlm.nih.gov/35602902/
4. Hong, Seong-Ho, Chang, Seung-Hee, Cho, Kyung-Cho, Park, Jongsun, Cho, Myung-Haing. . Endoplasmic reticulum-Golgi intermediate compartment protein 3 knockdown suppresses lung cancer through endoplasmic reticulum stress-induced autophagy. In Oncotarget, 7, 65335-65347. doi:10.18632/oncotarget.11678. https://pubmed.ncbi.nlm.nih.gov/27588471/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen