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C57BL/6JCya-Mtcl1em1/Cya
Common Name:
Mtcl1-KO
Product ID:
S-KO-19295
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mtcl1-KO
Strain ID
KOCMP-68617-Mtcl1-B6J-VB
Gene Name
Mtcl1
Product ID
S-KO-19295
Gene Alias
1110012J17Rik; Ccdc165; D130071O13; Kiaa0802; Soga2; mKIAA0802; t8219b25
Background
C57BL/6JCya
NCBI ID
68617
Modification
Conventional knockout
Chromosome
17
Phenotype
MGI:1915867
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mtcl1em1/Cya mice (Catalog S-KO-19295) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000086693
NCBI RefSeq
NM_172963
Target Region
Exon 1
Size of Effective Region
~4.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Mtcl1, or microtubule cross-linking factor 1, is a protein-coding gene. It is crucial for microtubule organization, participating in various biological processes such as neuronal function, cell polarity establishment, and chromosome segregation. It is associated with pathways like Wnt/β-catenin in cancer development [1]. Genetic models, especially knockout mouse models, are valuable for studying its functions.

In vivo knockdown of Mtcl1 in cerebellar Purkinje cells causes loss of axonal polarity and AnkG mislocalization, indicating its role in maintaining the axon initial segment [2]. Mtcl1 gene disruption in mice results in abnormal motor coordination with Purkinje cell degeneration, suggesting its possible involvement in spinocerebellar ataxia [2]. In human cells, knockdown of its related protein SOGA2/MTCL1 shows that it is required for faithful chromosome segregation [3]. In laryngeal squamous cell carcinoma, circular RNA MTCL1 (circMTCL1) promotes tumor progression by inhibiting C1QBP ubiquitin degradation and activating Wnt/β-catenin signaling [1]. In Hirschsprung's disease, Circ-MTCL1 regulates cell proliferation and migration by sponging miR-145-5p to target SMAD3 [4].

In conclusion, Mtcl1 plays essential roles in maintaining neuronal axon structure, ensuring accurate chromosome segregation, and is involved in cancer and congenital disorder development. The use of gene knockout mouse models has significantly contributed to understanding its functions in these disease-related biological processes.

References:
1. Wang, Zheng, Sun, Anqi, Yan, Aihui, Wu, Huizhe, Li, Kai. 2022. Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation. In Molecular cancer, 21, 92. doi:10.1186/s12943-022-01570-4. https://pubmed.ncbi.nlm.nih.gov/35366893/
2. Satake, Tomoko, Yamashita, Kazunari, Hayashi, Kenji, Yuzaki, Michisuke, Suzuki, Atsushi. 2017. MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment. In The EMBO journal, 36, 1227-1242. doi:10.15252/embj.201695630. https://pubmed.ncbi.nlm.nih.gov/28283581/
3. Ferreira, Luísa T, Logarinho, Elsa, Macedo, Joana C, Maia, Ana Rita R, Maiato, Helder. 2021. SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells. In Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 29, 159-173. doi:10.1007/s10577-021-09651-8. https://pubmed.ncbi.nlm.nih.gov/33587225/
4. Chen, Wang, Caiyun, Luo, Yang, Yang, Kai, Wu, Liucheng, Yang. 2023. Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease. In Pediatric surgery international, 40, 25. doi:10.1007/s00383-023-05621-9. https://pubmed.ncbi.nlm.nih.gov/38127107/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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