C57BL/6JCya-Ces2fem1/Cya
Common Name
Ces2f-KO
Product ID
S-KO-19387
Backgroud
C57BL/6JCya
Strain ID
KOCMP-71903-Ces2f-B6J-VC
When using this mouse strain in a publication, please cite “Ces2f-KO Mouse (Catalog S-KO-19387) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ces2f-KO
Strain ID
KOCMP-71903-Ces2f-B6J-VC
Gene Name
Product ID
S-KO-19387
Gene Alias
2310038E17Rik, A430088E12
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
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Strain Description
Ensembl Number
ENSMUST00000076384
NCBI RefSeq
NM_001079865
Target Region
Exon 3
Size of Effective Region
~1.1 kb
Overview of Gene Research
Ces2f is one of the genes belonging to the carboxylesterase 2 (Ces2) family. Carboxylesterases are phase I enzymes crucial for xenobiotic clearance and lipid metabolism. Understanding Ces2f's function can be facilitated by genetic models such as knockout (KO) mouse models.
In the study, E4bp4 -/- (E4bp4 -deficient) mice, a type of KO mouse model, showed down-regulation of an array of hepatic Ces genes including Ces2f. E4bp4 knockdown in Hepa-1c1c7 cells also reduced the expression of Ces2f. These findings suggest that E4bp4 is involved in regulating the expression of Ces2f. Since Ces2f is part of the Ces family related to xenobiotic metabolism, the KO models imply that E4bp4's regulation of Ces2f may impact the metabolism of xenobiotics [1].
In conclusion, Ces2f, as part of the Ces family, is important for xenobiotic clearance and lipid metabolism. The study using E4bp4 -/- KO mouse models reveals that E4bp4's regulation of Ces2f can influence the metabolism of relevant substances. This contributes to understanding the role of Ces2f in xenobiotic-related biological processes and potentially related disease conditions [1].
References：
1. Zhao, Mengjing, Zhang, Tianpeng, Yu, Fangjun, Guo, Lianxia, Wu, Baojian. 2018. E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice. In Biochemical pharmacology, 152, 293-301. doi:10.1016/j.bcp.2018.04.005. https://pubmed.ncbi.nlm.nih.gov/29653076/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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