C57BL/6JCya-A430005L14Rikem1/Cya
Common Name:
A430005L14Rik-KO
Product ID:
S-KO-19573
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
A430005L14Rik-KO
Strain ID
KOCMP-97159-A430005L14Rik-B6J-VA
Gene Name
Product ID
S-KO-19573
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-A430005L14Rikem1/Cya mice (Catalog S-KO-19573) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000058393
NCBI RefSeq
NM_175287
Target Region
Exon 2~3
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
A430005L14Rik, also known as C1orf174, is a gene whose function in relation to hearing has been investigated. Its precise normal cellular function and associated pathways remain to be fully characterized, but its study through genetic models can offer insights into biological processes related to auditory function [1].
In a study, gene knockdown in mouse models was used to analyze the role of candidate genes in age-related hearing loss (ARHL). A430005L14Rik mutants showed worse recovery from noise-induced damage than controls, indicating its possible role in the process of recovering from auditory damage [1].
In conclusion, A430005L14Rik appears to play a role in the recovery process after noise-induced hearing damage. The use of gene-knockdown mouse models has been crucial in revealing this aspect of its function in the context of ARHL, highlighting its potential importance in understanding the genetics of hearing-related disorders [1].
References：
1. Ingham, Neil J, Rook, Victoria, Di Domenico, Francesca, Buniello, Annalisa, Steel, Karen P. 2020. Functional analysis of candidate genes from genome-wide association studies of hearing. In Hearing research, 387, 107879. doi:10.1016/j.heares.2019.107879. https://pubmed.ncbi.nlm.nih.gov/31927188/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen