C57BL/6JCya-Aadacl3em1/Cya
Common Name:
Aadacl3-KO
Product ID:
S-KO-19756
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Aadacl3-KO
Strain ID
KOCMP-230883-Aadacl3-B6J-VB
Gene Name
Product ID
S-KO-19756
Gene Alias
Gm435
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Aadacl3em1/Cya mice (Catalog S-KO-19756) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000105749
NCBI RefSeq
NM_001085503
Target Region
Exon 1~4
Size of Effective Region
~8.6 kb
Detailed Document
Overview of Gene Research
Aadacl3 is a gene that may be involved in fat deposition in sheep, as indicated by a study on Siberian native sheep breeds [3]. In addition, in Chinese fine-wool sheep, it was identified among genes associated with body weight traits, and genes annotated by related SNPs were found to be mainly involved in skeletal muscle development and lipid metabolism [2].
In Finnish sarcoidosis patients, variations in Aadacl3 were associated with resolved disease, as shown in a whole-exome sequencing study [1]. This suggests a potential role of Aadacl3 in the prognosis of sarcoidosis.
In conclusion, Aadacl3 seems to be related to body weight-related traits such as fat deposition and skeletal muscle development in sheep. In humans, it may have implications for the prognosis of sarcoidosis. These findings from different species provide insights into the biological functions of Aadacl3 and its potential roles in disease-related processes.
References：
1. Lahtela, Elisa, Kankainen, Matti, Sinisalo, Juha, Selroos, Olof, Lokki, Marja-Liisa. 2019. Exome Sequencing Identifies Susceptibility Loci for Sarcoidosis Prognosis. In Frontiers in immunology, 10, 2964. doi:10.3389/fimmu.2019.02964. https://pubmed.ncbi.nlm.nih.gov/31921204/
2. Lu, Zengkui, Yue, Yaojing, Yuan, Chao, Guo, Tingting, Yang, Bohui. 2020. Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep. In Animals : an open access journal from MDPI, 10, . doi:10.3390/ani10010170. https://pubmed.ncbi.nlm.nih.gov/31963922/
3. Sweet-Jones, J, Yurchenko, A A, Igoshin, A V, Swain, M T, Larkin, D M. 2020. Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits. In Animal genetics, 52, 126-131. doi:10.1111/age.13015. https://pubmed.ncbi.nlm.nih.gov/33107621/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen