C57BL/6JCya-Csem1/Cya
Common Name
Cs-KO
Product ID
S-KO-19807
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12974-Cs-B6J-VB
When using this mouse strain in a publication, please cite “Cs-KO Mouse (Catalog S-KO-19807) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cs-KO
Strain ID
KOCMP-12974-Cs-B6J-VB
Gene Name
Product ID
S-KO-19807
Gene Alias
2610511A05Rik, 9030605P22Rik, Ahl4, Cis
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000005826
NCBI RefSeq
NM_026444
Target Region
Exon 5~7
Size of Effective Region
~6.3 kb
Overview of Gene Research
Cs is not clearly defined as a gene in the provided references. However, "CS" may refer to chondroitin sulfate, a glycosaminoglycan. Chondroitin sulfate is one of the major and widespread glycosaminoglycans, playing a vital role in various normal physiological and pathological processes, showing biological activities like anti-oxidation, anti-atherosclerosis, anti-thrombosis, and having insignificant immunogenicity [2].
The synthesis of chondroitin sulfate-E (CS-E) oligosaccharides was developed using a postglycosylation-transformation strategy, which provided flexibility for group transformation and derivatization, facilitating the examination of the structure-activity relationship (SAR) of CS-E molecules [1]. Additionally, there has been progress in the chemical, enzymatic and chemoenzymatic synthesis of CS and its derivatives, aiming to obtain CS with well-controlled chain lengths for reliable drug development [2].
In conclusion, chondroitin sulfate (CS) is important in various physiological and pathological processes. The research on its synthesis and structure-activity relationship helps in understanding its biological functions and provides a basis for drug development related to the associated physiological and pathological conditions.
References：
1. Yang, Shuang, Liu, Qi, Zhang, Guangyan, Zhao, Zhehui, Lei, Pingsheng. 2018. An Approach to Synthesize Chondroitin Sulfate-E (CS-E) Oligosaccharide Precursors. In The Journal of organic chemistry, 83, 5897-5908. doi:10.1021/acs.joc.8b00157. https://pubmed.ncbi.nlm.nih.gov/29756448/
2. Ji, Yuan, Zhang, Shilin, Qiao, Meng, Zhang, Xing, Huang, He. 2020. Synthesis of structurally defined chondroitin sulfate: Paving the way to the structure-activity relationship studies. In Carbohydrate polymers, 248, 116796. doi:10.1016/j.carbpol.2020.116796. https://pubmed.ncbi.nlm.nih.gov/32919534/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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