Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Ankrd13dem1/Cya
Common Name:
Ankrd13d-KO
Product ID:
S-KO-19810
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ankrd13d-KO
Strain ID
KOCMP-68423-Ankrd13d-B6J-VB
Gene Name
Ankrd13d
Product ID
S-KO-19810
Gene Alias
0710001P18Rik
Background
C57BL/6JCya
NCBI ID
68423
Modification
Conventional knockout
Chromosome
19
Phenotype
MGI:1915673
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ankrd13dem1/Cya mice (Catalog S-KO-19810) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000056888
NCBI RefSeq
NM_026720
Target Region
Exon 2~6
Size of Effective Region
~2.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ankrd13d, short for Ankyrin repeat domain-containing protein 13D, is involved in multiple biological processes. It contains ubiquitin-interacting motifs (UIM) and may act as a molecular scaffold in the endocytic pathway [2,3]. It has potential importance in diseases, as genes in the endocytic pathway, including Ankrd13d, may contribute to Alzheimer's disease [3].

In renal cell carcinoma, Ankrd13d was identified as a key immune regulator. It is mainly expressed in immune cells, positively correlated with Treg cell infiltration, and also with immune-related genes like PDCD1, CTLA4, etc. Targeting Ankrd13d with immune checkpoints blockade may be a promoting strategy for renal cell carcinoma immunotherapy [1].

In addition, in the context of heart failure, Ankrd13d was identified as a potential genetic contributor through an integrative transomics approach, although independent replication is needed [4]. Genome-wide association studies also found that Ankrd13d is associated with arachidonic acid in Hispanic Americans, indicating its role in fatty acid-related genetics [5,6]. In clear cell renal cell carcinoma, Ankrd13d has a strong positive correlation with TRIM46, suggesting its potential involvement in tumor-associated pathways [7].

In summary, Ankrd13d is implicated in immune regulation, endocytic processes, heart failure, fatty acid genetics, and renal cell carcinoma-related pathways. The findings from these studies contribute to understanding its role in various biological processes and disease conditions, potentially guiding future research and therapeutic strategies.

References:
1. Zhou, Wenqian, Huang, Yonghe, Liu, Jing, Liu, Yuqing, Yu, Chen. 2024. Identification of ANKRD13D as a potential target in renal cell carcinomas. In The International journal of biological markers, 39, 149-157. doi:10.1177/03936155241236498. https://pubmed.ncbi.nlm.nih.gov/38449090/
2. Mattioni, Anna, Boldt, Karsten, Auciello, Giulio, Cesareni, Gianni, Santonico, Elena. 2020. Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. In The FEBS journal, 287, 3526-3550. doi:10.1111/febs.15226. https://pubmed.ncbi.nlm.nih.gov/31985874/
3. Zhan, Lingyu, Li, Jiajin, Jew, Brandon, Sul, Jae Hoon. 2021. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. In PLoS genetics, 17, e1009772. doi:10.1371/journal.pgen.1009772. https://pubmed.ncbi.nlm.nih.gov/34516545/
4. Andersson, Charlotte, Lin, Honghuang, Liu, Chunyu, Larson, Martin G, Vasan, Ramachandran S. 2019. Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study. In Circulation. Genomic and precision medicine, 12, e002489. doi:10.1161/CIRCGEN.118.002489. https://pubmed.ncbi.nlm.nih.gov/31703168/
5. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci M, Lemaitre, Rozenn N, Manichaikul, Ani. 2023. Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts. In Communications biology, 6, 852. doi:10.1038/s42003-023-05219-w. https://pubmed.ncbi.nlm.nih.gov/37587153/
6. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci, Lemaitre, Rozenn, Manichaikul, Ani. 2023. Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts. In Research square, , . doi:10.21203/rs.3.rs-2073736/v1. https://pubmed.ncbi.nlm.nih.gov/36865120/
7. Ren, Xiang-Bin, Zhao, Jing, Liang, Xue-Feng, Jiang, Shao-Bo, Xiang, Yu-Zhu. 2021. Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses. In Frontiers in medicine, 8, 785331. doi:10.3389/fmed.2021.785331. https://pubmed.ncbi.nlm.nih.gov/34881275/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest