C57BL/6JCya-Ankrd13dem1/Cya
Common Name
Ankrd13d-KO
Product ID
S-KO-19810
Backgroud
C57BL/6JCya
Strain ID
KOCMP-68423-Ankrd13d-B6J-VB
When using this mouse strain in a publication, please cite “Ankrd13d-KO Mouse (Catalog S-KO-19810) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ankrd13d-KO
Strain ID
KOCMP-68423-Ankrd13d-B6J-VB
Gene Name
Product ID
S-KO-19810
Gene Alias
0710001P18Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000056888
NCBI RefSeq
NM_026720
Target Region
Exon 2~6
Size of Effective Region
~2.3 kb
Overview of Gene Research
Ankrd13d, short for Ankyrin repeat domain-containing protein 13D, is involved in multiple biological processes. It contains ubiquitin-interacting motifs (UIM) and may act as a molecular scaffold in the endocytic pathway [2,3]. It has potential importance in diseases, as genes in the endocytic pathway, including Ankrd13d, may contribute to Alzheimer's disease [3].
In renal cell carcinoma, Ankrd13d was identified as a key immune regulator. It is mainly expressed in immune cells, positively correlated with Treg cell infiltration, and also with immune-related genes like PDCD1, CTLA4, etc. Targeting Ankrd13d with immune checkpoints blockade may be a promoting strategy for renal cell carcinoma immunotherapy [1].
In addition, in the context of heart failure, Ankrd13d was identified as a potential genetic contributor through an integrative transomics approach, although independent replication is needed [4]. Genome-wide association studies also found that Ankrd13d is associated with arachidonic acid in Hispanic Americans, indicating its role in fatty acid-related genetics [5,6]. In clear cell renal cell carcinoma, Ankrd13d has a strong positive correlation with TRIM46, suggesting its potential involvement in tumor-associated pathways [7].
In summary, Ankrd13d is implicated in immune regulation, endocytic processes, heart failure, fatty acid genetics, and renal cell carcinoma-related pathways. The findings from these studies contribute to understanding its role in various biological processes and disease conditions, potentially guiding future research and therapeutic strategies.
References：
1. Zhou, Wenqian, Huang, Yonghe, Liu, Jing, Liu, Yuqing, Yu, Chen. 2024. Identification of ANKRD13D as a potential target in renal cell carcinomas. In The International journal of biological markers, 39, 149-157. doi:10.1177/03936155241236498. https://pubmed.ncbi.nlm.nih.gov/38449090/
2. Mattioni, Anna, Boldt, Karsten, Auciello, Giulio, Cesareni, Gianni, Santonico, Elena. 2020. Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. In The FEBS journal, 287, 3526-3550. doi:10.1111/febs.15226. https://pubmed.ncbi.nlm.nih.gov/31985874/
3. Zhan, Lingyu, Li, Jiajin, Jew, Brandon, Sul, Jae Hoon. 2021. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. In PLoS genetics, 17, e1009772. doi:10.1371/journal.pgen.1009772. https://pubmed.ncbi.nlm.nih.gov/34516545/
4. Andersson, Charlotte, Lin, Honghuang, Liu, Chunyu, Larson, Martin G, Vasan, Ramachandran S. 2019. Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study. In Circulation. Genomic and precision medicine, 12, e002489. doi:10.1161/CIRCGEN.118.002489. https://pubmed.ncbi.nlm.nih.gov/31703168/
5. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci M, Lemaitre, Rozenn N, Manichaikul, Ani. 2023. Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts. In Communications biology, 6, 852. doi:10.1038/s42003-023-05219-w. https://pubmed.ncbi.nlm.nih.gov/37587153/
6. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci, Lemaitre, Rozenn, Manichaikul, Ani. 2023. Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts. In Research square, , . doi:10.21203/rs.3.rs-2073736/v1. https://pubmed.ncbi.nlm.nih.gov/36865120/
7. Ren, Xiang-Bin, Zhao, Jing, Liang, Xue-Feng, Jiang, Shao-Bo, Xiang, Yu-Zhu. 2021. Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses. In Frontiers in medicine, 8, 785331. doi:10.3389/fmed.2021.785331. https://pubmed.ncbi.nlm.nih.gov/34881275/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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