C57BL/6JCya-Il1bem1/Cya
Common Name:
Il1b-KO
Product ID:
S-KO-19937
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Il1b-KO
Strain ID
KOCMP-16176-Il1b-B6J-VA
Gene Name
Product ID
S-KO-19937
Gene Alias
IL-1beta; Il-1b
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Il1bem1/Cya mice (Catalog S-KO-19937) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000028881
NCBI RefSeq
NM_008361
Target Region
Exon 4~5
Size of Effective Region
~1.9 kb
Detailed Document
Overview of Gene Research
Il1b, also known as interleukin-1β, is a key cytokine in the inflammatory response pathway. It is essential for the host-response against pathogens, yet it can exacerbate damage during chronic diseases and acute tissue injury. Its secretion does not follow the conventional ER-Golgi route [2].
In PD-1 inhibitor-induced inflammatory arthritis (PD-1-IA), there is a predominant expansion of IL1Bhi myeloid cells with enhanced NLRP3 inflammasome activity, which might communicate with exhausted CD8+ T cells via certain axes, suggesting different cellular and molecular pathways compared to rheumatoid arthritis. IL1Bhi macrophages could be a therapeutic target in PD-1-IA [1]. Also, exposure to BaP/BPDE up-regulates lnc-HZ06-regulated IL1B, causing trophoblast cell dysfunctions and miscarriage [3].
In conclusion, Il1b plays a crucial role in the inflammatory response. Studies on PD-1-IA and miscarriage demonstrate its significance in specific disease conditions. Understanding Il1b function through these models may offer insights into treating related diseases.
References：
1. Zhou, Ziyue, Zhou, Xiaoxiang, Jiang, Xu, Yang, Huaxia, Zhang, Xuan. 2024. Single-cell profiling identifies IL1Bhi macrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis. In Nature communications, 15, 2107. doi:10.1038/s41467-024-46195-x. https://pubmed.ncbi.nlm.nih.gov/38453911/
2. Lopez-Castejon, Gloria, Brough, David. 2011. Understanding the mechanism of IL-1β secretion. In Cytokine & growth factor reviews, 22, 189-95. doi:10.1016/j.cytogfr.2011.10.001. https://pubmed.ncbi.nlm.nih.gov/22019906/
3. Guo, Jiarong, Zhao, Jingsong, Tian, Peng, Yang, Yang, Zhang, Huidong. 2024. BaP/BPDE exposure causes human trophoblast cell dysfunctions and induces miscarriage by up-regulating lnc-HZ06-regulated IL1B. In Journal of hazardous materials, 476, 134741. doi:10.1016/j.jhazmat.2024.134741. https://pubmed.ncbi.nlm.nih.gov/38991640/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen