C57BL/6JCya-Cfap36em1/Cya
Common Name:
Cfap36-KO
Product ID:
S-KO-20031
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Contact for Pricing
Basic Information
Strain Name
Cfap36-KO
Strain ID
KOCMP-216618-Cfap36-B6J-VB
Gene Name
Product ID
S-KO-20031
Gene Alias
2300003H10; 4931428D14Rik; Ccdc104
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cfap36em1/Cya mice (Catalog S-KO-20031) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020754
NCBI RefSeq
NM_025740
Target Region
Exon 2
Size of Effective Region
~1.8 kb
Detailed Document
Overview of Gene Research
Cfap36, also known as CCDC104 or BARTL1, is a gene with a protein product that has been implicated in ciliary function. Cilia are vital cellular protrusions involved in numerous developmental signaling pathways. Cfap36 binds to Arl3, a ciliary protein known for releasing myristoylated and farnesylated ciliary cargo molecules. This interaction seems to suggest a role for Cfap36 within the ciliary Arl3 transport network, potentially regulating the presentation of active Arl3 to its GTPase-activating protein RP2 or its membrane binding at the transition zone [1].
Cfap36 is also among the cross-species differential transcript usage (DTU) genes identified in a study of mammalian oocytes at germinal vesicle (GV) and metaphase II (MII) stages. GO term enrichment analysis of these cross-species DTU genes indicates their alignment with RNA and cell-cycle control mechanisms during oocyte maturation, suggesting an important role for Cfap36 in this process [2].
In conclusion, Cfap36 appears to be involved in both ciliary function and oocyte maturation processes. Its role in ciliary function through interaction with Arl3 and its potential function in oocyte maturation as a DTU gene provide valuable insights into biological mechanisms. Understanding Cfap36 could potentially contribute to research in areas related to cilia-associated diseases and reproductive biology.
References：
1. Lokaj, Mandy, Kösling, Stefanie K, Koerner, Carolin, Boldt, Karsten, Wittinghofer, Alfred. 2015. The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. In Structure (London, England : 1993), 23, 2122-32. doi:10.1016/j.str.2015.08.016. https://pubmed.ncbi.nlm.nih.gov/26455799/
2. Sananmuang, Thanida, Puthier, Denis, Nguyen, Catherine, Chokeshaiusaha, Kaj. 2023. Differential transcript usage across mammalian oocytes at the germinal vesicle and metaphase II stages. In Theriogenology, 215, 1-9. doi:10.1016/j.theriogenology.2023.11.016. https://pubmed.ncbi.nlm.nih.gov/37995439/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen