C57BL/6JCya-Ngpem1/Cya
Common Name
Ngp-KO
Product ID
S-KO-20328
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18054-Ngp-B6J-VB
Status
When using this mouse strain in a publication, please cite “Ngp-KO Mouse (Catalog S-KO-20328) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ngp-KO
Strain ID
KOCMP-18054-Ngp-B6J-VB
Gene Name
Product ID
S-KO-20328
Gene Alias
bectenecin
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000035061
NCBI RefSeq
NM_008694
Target Region
Exon 1~4
Size of Effective Region
~3.5 kb
Overview of Gene Research
Ngp, Neutrophilic granule protein, belongs to the cystatin superfamily. It plays a crucial role in regulating the body's immune response, especially in macrophages. Ngp is involved in inflammatory responses and phagocytosis processes, which are essential for the body's defense against pathogens [1].
In a study, it was observed that Ngp levels significantly increased in peritoneal macrophages isolated from mice challenged with E. coli or lipopolysaccharide (LPS) [1]. Ngp overexpression in LPS-induced RAW264.7 cells reduced the production of pro-inflammatory cytokines TNF-α and IL-1β via suppressing the NF-κB (p65 and p50) signalling pathway, while also inducing the anti-inflammatory cytokine IL-10 [1]. Moreover, upregulated Ngp enhanced the phagocytosis of E. coli by RAW cells [1].
In conclusion, Ngp is an important host defense component that modulates inflammatory responses and phagocytosis by activated macrophages. These findings from mouse-based studies suggest that Ngp could potentially be a therapeutic target for treating inflammatory-based diseases [1].
References：
1. Liu, Kuan, Tian, Li-Xing, Tang, Xin, Chen, Tao, Liang, Hua-Ping. 2020. Neutrophilic granule protein (NGP) attenuates lipopolysaccharide-induced inflammatory responses and enhances phagocytosis of bacteria by macrophages. In Cytokine, 128, 155001. doi:10.1016/j.cyto.2020.155001. https://pubmed.ncbi.nlm.nih.gov/32035329/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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