C57BL/6JCya-Rhox1em1/Cya
Common Name
Rhox1-KO
Product ID
S-KO-20372
Backgroud
C57BL/6JCya
Strain ID
KOCMP-385343-Rhox1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Rhox1-KO Mouse (Catalog S-KO-20372) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Rhox1-KO
Strain ID
KOCMP-385343-Rhox1-B6J-VA
Gene Name
Product ID
S-KO-20372
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000115210
NCBI RefSeq
NM_001025084
Target Region
Exon 2~3
Size of Effective Region
~1.7 kb
Overview of Gene Research
Rhox1, a member of the reproductive homeobox on the X chromosome (RHOX) gene family, is crucial for reproduction. Rhox genes are mainly expressed in reproductive tissues and have a role in regulating various reproductive features, especially gametogenesis in mammals [1,2].
In the mouse, Rhox genes are organized into three clusters (α, β, and γ) on the X chromosome. Rhox1, belonging to the α-cluster, has been shown to play a role in the differentiation of primordial germ cells and in spermatogenesis [1].
In conclusion, Rhox1 is essential for reproductive processes, specifically in the differentiation of primordial germ cells and spermatogenesis as revealed through studies in mouse models. Understanding its function can potentially contribute to a better understanding of infertility and associated human phenotypes related to impaired spermatogenesis [1].
References：
1. Le Beulze, Morgane, Daubech, Cécile, Balde-Camara, Aissatu, Ghieh, Farah, Vialard, François. 2023. Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development. In Genes, 14, . doi:10.3390/genes14091685. https://pubmed.ncbi.nlm.nih.gov/37761825/
2. Lee, Sang-Eun, Lee, Su-Yeon, Lee, Kyung-Ah. 2013. Rhox in mammalian reproduction and development. In Clinical and experimental reproductive medicine, 40, 107-14. doi:10.5653/cerm.2013.40.3.107. https://pubmed.ncbi.nlm.nih.gov/24179867/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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