C57BL/6JCya-Asphd2em1/Cya
Common Name:
Asphd2-KO
Product ID:
S-KO-20402
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Asphd2-KO
Strain ID
KOCMP-72898-Asphd2-B6J-VB
Gene Name
Product ID
S-KO-20402
Gene Alias
2900006N09Rik; 9230106G13Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Asphd2em1/Cya mice (Catalog S-KO-20402) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031291
NCBI RefSeq
NM_001357015
Target Region
Exon 1
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Asphd2, whose specific function and common aliases are not detailed in the provided references, is potentially involved in metabolism and viral replication cycles pathways. Genes like ASPHD2 were found to be regulated in monkeypox virus (MPV)-infected HeLa cells at 2-hour incubation, suggesting its possible role in MPV-related biological processes [1]. Additionally, in the context of melioidosis, a diagnostic 6-mRNA signature including Asphd2 was identified, which could potentially distinguish Burkholderia pseudomallei-caused sepsis from sepsis caused by other organisms, indicating its significance in host-pathogen interaction and disease diagnosis [2].
No information regarding KO/CKO mouse models or other loss-of-function experiments was provided in the references.
In summary, Asphd2 appears to be associated with monkeypox-related biological processes and could potentially serve as a biomarker for diagnosing septicaemic melioidosis. Although the exact functions of Asphd2 remain to be further explored through in-vivo studies such as gene knockout models, its potential importance in disease-related pathways is emerging from current research.
References:
1. Anuraga, Gangga, Lang, Jilu, Xuan, Do Thi Minh, Wang, Wei-Jan, Wang, Chih-Yang. 2023. Integrated bioinformatics approaches to investigate alterations in transcriptomic profiles of monkeypox infected human cell line model. In Journal of infection and public health, 17, 60-69. doi:10.1016/j.jiph.2023.10.035. https://pubmed.ncbi.nlm.nih.gov/37992435/
2. Yin, Li, Chen, Yuanyuan, Fu, Tingting, Liu, Lin, Xia, Qianfeng. . Identification of candidate blood biomarkers for the diagnosis of septicaemic melioidosis based on WGCNA. In Artificial cells, nanomedicine, and biotechnology, 50, 252-259. doi:10.1080/21691401.2022.2126490. https://pubmed.ncbi.nlm.nih.gov/36191125/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen