The huHSC-NKG-hIL15 mouse refers to an immune system humanized mouse model constructed by transplanting human hematopoietic stem cells (HSC) into NKG-hIL15 mice after sub-lethal dose irradiation. This model can reconstitute various immune cells, has a long lifespan, and is particularly effective in rebuilding human NK cells, which can aid in the development of NK cell-related tumor immunotherapies.

PBMC humanized mice refer to the immune system humanized mouse model constructed by transplanting human peripheral blood mononuclear cells (PBMC) into immunodeficient mice (such as NKG). NKG mice transplanted with PBMC (huPBMC-NKG) have high efficiency and fast immune reconstitution. Human T cells generated after PBMC injection will attack mouse recipient cells, resulting in graft-versus-host disease (GvHD), so this model can be used to evaluate GvHD drugs.

huHSC-NKG mice are immune system humanized mouse models constructed by transplanting human hematopoietic stem cells (HSC) into NKG mice after sub-lethal dose irradiation. This model has a long lifespan and can successfully reconstitute a variety of immune cells. Furthermore, huHSC-NKG mice typically do not develop graft-versus-host disease (GvHD) and the reconstitution period can be lengthy.

The huHSC-NKG-ProF mouse is the latest enhanced version of the huHSC-NKG series, where "Pro" indicates the enhanced series and "F" indicates full immune reconstitution. This mouse model uses advanced neonatal techniques optimised to develop a variety of human immune cells, including lymphoid T cells, B cells and NK cells, as well as myeloid dendritic cells (DCs), monocytes, macrophages and granulocytes. Due to its ability to reconstitute multiple types of human-derived immune cells, the huHSC-NKG-ProF mouse is also referred to as a fully humanised immune system mouse. It is an ideal model for immunological research, antibody-dependent cellular cytotoxicity (ADCC) studies and the development of tumor vaccines, cellular therapies and other biopharmaceuticals.

The NKG-hSIRPα mouse is a humanized model constructed by replacing the exon 2 coding region plus partial intron 2 of the mouse Sirpa gene in situ with the "Human SIRPA CDS-3'UTR of Mouse Sirpa-WPRE-BGH pA" cassette. The homozygous NKG-hSIRPα mice are viable and fertile. Compared with NKG mice, NKG-hSIRPα mice further inhibit the phagocytosis of transplanted tumors by host macrophages through enhancing the function of the CD47-SIRPα signaling pathway, thus accelerating tumor growth. This model provides a crucial experimental platform for studying the ability of CAR-M therapy to overcome the immunosuppressive microenvironment, as well as for developing anti-tumor drugs targeting the CD47/SIRPα pathway.

The NKG-hFcRn mouse is a humanized model constructed by replacing the exon 2 coding region plus partial intron 2 of the mouse Fcgrt gene in situ with the "Human FCGRT CDS-3'UTR of Mouse Fcgrt-WPRE-BGH pA" cassette. It expresses human FcRn to replace the endogenous mouse FcRn. The homozygous NKG-hFcRn mice are viable and fertile. This model may help evaluate the pharmacokinetics/pharmacodynamics of human immunoglobulin G in transplantation research, human tumor xenografts, and mouse tumor allografts.

NKG-SGM3/hIL6/Kit*V831M mice are mouse models obtained by mating KIT W41 mutation (V831M) mouse models (Catalog Number: I001175) with IL6 humanized mouse models (Catalog Number: I001176) and IL3, KITLG and CSF2 triple humanized mouse models (Catalog Number: I001177). These mice express human IL6, IL3, KITLG, and CSF2 genomic sequences, as well as mouse KIT genomic sequences carrying the W41 mutation (V831M). This model is a valuable tool for immuno-oncology, immunology, and infectious disease research.

NKG-SGM3 mice constructed by integrating human KITLG, CSF2, and IL3 genes into the genome of NKG mice can effectively enhance myeloid differentiation and improve the transplantation efficiency of hematopoietic and acute myeloid leukemia cells and thus are valuable for immuno-oncology, immunology, and infectious disease research.

NKG-hIL6 mice were constructed by introducing the human IL6 gene into the genome of NKG mice. Compared to NKG mice, NKG-hIL6 mice can efficiently and rapidly rebuild human CD45+ leukocytes during HSC reconstruction. These mice are valuable for developing tumor immunotherapies and drug evaluations.

The NKG-Kit*V831M mouse strain is generated by introducing the W41 mutation (V831M) into the KIT gene of the NKG mouse. Compared to standard NKG mice, these mice eliminate the need for irradiation during HSC reconstitution, thereby avoiding the deleterious effects of irradiation on the hematopoietic, gastrointestinal, and nervous systems. This feature renders NKG-Kit*V831M mice an invaluable tool for developing and evaluating tumor immunotherapies and conducting drug efficacy assessments.