NKG-SGM3/hIL6/Kit*V831M
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Strain Description
NKG-SGM3/hIL6/Kit*V831M mice are mouse models obtained by mating KIT W41 mutation (V831M) mouse models (Catalog Number: I001175) with IL6 humanized mouse models (Catalog Number: I001176) and IL3, KITLG and CSF2 triple humanized mouse models (Catalog Number: I001177). These mice express human IL6, IL3, KITLG, and CSF2 genomic sequences, as well as mouse KIT genomic sequences carrying the W41 mutation (V831M). This model is a valuable tool for immuno-oncology, immunology, and infectious disease research.
Application Area
Construction of humanized mouse models for the immune system
Studies on the human immune and hematopoietic systems
Xenotransplantation of human cell lines (CDX) for drug screening and efficacy evaluation
Xenotransplantation of patient-derived tumor tissues (PDX) for drug screening and efficacy evaluation
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