Pamphlet
Human Immune System Reconstruction Models
This pamphlet introduces Cyagen’s mouse models for human immune system reconstruction, featuring PBMC and HSC-based strategies validated in oncology, immunology, and infectious disease research.
Overview
Cyagen offers robust PBMC and HSC humanized mouse models built on highly immunodeficient NKG backgrounds. These models enable rapid or long-term reconstruction of human T, B, NK, and myeloid cells. The pamphlet details model types, reconstitution timelines, immune profiles, application areas (e.g., GvHD, immunotherapy, infectious disease), and validation data for tumor response, cytokine function, and immunotoxicity testing.
Key Insights
Explore validated PBMC and HSC humanized mouse models for translational immunology and drug evaluation.
- Overview of huPBMC and huHSC reconstitution models on NKG mice
- Timeline and efficiency of immune cell development (T, B, NK, myeloid)
- Application areas: tumor immunotherapy, GvHD, autoimmune disease, virus response
- Validation data: immune cell distribution, survival curves, histological results
- Case studies: drug testing (BiTEs, CAR-T, antibodies) and disease modeling
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