Poster
Advancing Dry AMD Research: Sodium lodate-Induced Mouse Models as Tools for Understanding Dry AMD Pathophysiology and Therapy
This poster details a sodium iodate-induced mouse model for studying dry age-related macular degeneration (AMD). Since dry AMD accounts for 90% of cases and features retinal pigment epithelial (RPE) cell apoptosis, this model accurately simulates advanced-stage pathology via oxidative stress. Furthermore, the poster demonstrates the model's utility by evaluating the therapeutic efficacy of Pegcetacoplan.
Overview
This poster presents an evaluation of the sodium iodate-induced dry AMD mouse model. It outlines the model's ability to replicate key pathological features, specifically RPE apoptosis and photoreceptor degeneration. The study highlights the validation of Pegcetacoplan as a therapeutic intervention. Results demonstrate that Pegcetacoplan significantly preserves outer nuclear layer (ONL) thickness , ameliorates retinal functional impairment measured by electroretinography (ERG) , and effectively suppresses C3 expression. This model serves as a robust platform for testing RPE-protective therapies.
Key Insights
Key highlights of this research poster include:
- Disease Relevance: The model accurately simulates advanced-stage dry AMD by triggering severe oxidative stress and subsequent RPE cell apoptosis.
- Structural Preservation: Optical coherence tomography (OCT) confirms that Pegcetacoplan treatment significantly alleviates retinal damage and retains greater ONL thickness.
- Functional Rescue: Electroretinography (ERG) recordings demonstrate that Pegcetacoplan ameliorates functional impairment in photoreceptors and inner retinal neurons.
- Target Mechanism: Quantitative PCR (qPCR) analysis shows that Pegcetacoplan effectively attenuates complement activation by significantly suppressing C3 expression.
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