C57BL/6JCya-Igfbp1em1flox/Cya
Common Name
Igfbp1-flox
Product ID
S-CKO-03060
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-16006-Igfbp1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Igfbp1-flox Mouse (Catalog S-CKO-03060) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Igfbp1-flox
Strain ID
CKOCMP-16006-Igfbp1-B6J-VA
Gene Name
Product ID
S-CKO-03060
Gene Alias
--
Background
C57BL/6JCya
Gene Full Name
insulin-like growth factor binding protein 1
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 11 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000020704
NCBI Transcript ID
NM_008341.4
Target Region
Exon 2~3
Size of Effective Region
~2.2 kb
Overview of Gene Research
Igfbp1, insulin-like growth factor binding protein 1, is a protein-coding gene. It binds to insulin-like growth factors (IGFs), modulating their bioavailability and activity, thus playing a role in multiple biological processes such as cell growth, metabolism, and differentiation. The IGF signaling pathway is one of the main associated pathways [6].
In pregnancy-related studies, placental Igfbp1 expression positively associates with insulin sensitivity at around 26 weeks of gestation. Low circulating Igfbp1 levels in early pregnancy can predict subsequent gestational diabetes mellitus (GDM) diagnosis, implicating its role in pregnancy glycemic physiology [1].
In preeclampsia, Igfbp1 expression in the placenta is increased. Overexpression of Igfbp1 in HTR-8/SVneo trophoblast cells inhibits their proliferation, invasion, migration, and apoptosis, and is related to MMP-26 expression, suggesting its role in preeclampsia pathophysiology [2]. Also, in Chinese Han women, the Igfbp1 SNP rs1065780A > G is associated with a decreased risk of preeclampsia, with the G genotype increasing Igfbp1 protein levels and improving pregnancy outcomes [4].
In cystitis, Igfbp1 suppresses its occurrence and development by stabilizing Umod expression through m6A modification, inhibiting the NF-κB and ERK signaling pathways [3].
In diabetes-related research, in prediabetic patients, lower IGF1 and higher Igfbp1 predict the incidence of type 2 diabetes mellitus (T2DM), indicating an impairment of beta-cell function [5]. In zebrafish, Igfbp1 promotes β-cell regeneration by potentiating α-to β-cell transdifferentiation, and in human islets, treatment with recombinant Igfbp1 in vitro increases the number of cells co-expressing insulin and glucagon, and high Igfbp1 levels reduce the risk of developing type-2 diabetes [6].
In gastric cancer, high Igfbp1 expression is associated with haematogenous metastasis and poor survival, and in stomach adenocarcinoma, low Igfbp1 mRNA expression is related to a shorter overall survival time, and Igfbp1 may inhibit immune cell infiltration in tumors [7,8]. In colorectal cancer, histone MARylation promotes Igfbp1 methylation, regulating lipid metabolism [9].
In conclusion, Igfbp1 is a gene with diverse functions, playing crucial roles in pregnancy-related diseases like GDM and preeclampsia, as well as in diseases such as cystitis, diabetes, and various cancers. Studies on Igfbp1 contribute to understanding the underlying mechanisms of these diseases, potentially providing new directions for diagnosis and treatment.
References：
1. Hivert, Marie-France, White, Frédérique, Allard, Catherine, Karumanchi, S Ananth, Powe, Camille E. 2024. Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes. In Nature medicine, 30, 1689-1695. doi:10.1038/s41591-024-02936-5. https://pubmed.ncbi.nlm.nih.gov/38627562/
2. Li, Xiujuan, Li, Chenxi, Wang, Ye, Su, Zhiying, Ye, Huiming. 2022. IGFBP1 inhibits the invasion, migration, and apoptosis of HTR-8/SVneo trophoblast cells in preeclampsia. In Hypertension in pregnancy, 41, 53-63. doi:10.1080/10641955.2022.2033259. https://pubmed.ncbi.nlm.nih.gov/35168459/
3. Yuan, Zuliang, Wang, Wenjing, Song, Shuang, Xu, Jing, Tao, Zhen. 2024. IGFBP1 stabilizes Umod expression through m6A modification to inhibit the occurrence and development of cystitis by blocking NF-κB and ERK signaling pathways. In International immunopharmacology, 134, 111997. doi:10.1016/j.intimp.2024.111997. https://pubmed.ncbi.nlm.nih.gov/38759370/
4. Peng, Xianglan, He, Dong, Peng, Rui, Chen, Yang, He, Hong. 2023. Associations between IGFBP1 gene polymorphisms and the risk of preeclampsia and fetal growth restriction. In Hypertension research : official journal of the Japanese Society of Hypertension, 46, 2070-2084. doi:10.1038/s41440-023-01309-8. https://pubmed.ncbi.nlm.nih.gov/37217731/
5. Meyer, Nina M T, Kabisch, Stefan, Dambeck, Ulrike, Weickert, Martin O, Pfeiffer, Andreas F H. 2022. Low IGF1 and high IGFBP1 predict diabetes onset in prediabetic patients. In European journal of endocrinology, 187, 555-565. doi:10.1530/EJE-22-0034. https://pubmed.ncbi.nlm.nih.gov/36005859/
6. Lu, Jing, Liu, Ka-Cheuk, Schulz, Nadja, Brismar, Kerstin, Andersson, Olov. 2016. IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation. In The EMBO journal, 35, 2026-44. doi:10.15252/embj.201592903. https://pubmed.ncbi.nlm.nih.gov/27516442/
7. Sato, Yuya, Inokuchi, Mikito, Takagi, Yoko, Kojima, Kazuyuki. . IGFBP1 Is a Predictive Factor for Haematogenous Metastasis in Patients With Gastric Cancer. In Anticancer research, 39, 2829-2837. doi:10.21873/anticanres.13411. https://pubmed.ncbi.nlm.nih.gov/31177120/
8. Luo, Xiao-Ye, Zhang, Yan-Ping, Zheng, Feng, Zhou, Liang. . Multiple bioinformatics analysis identifies IGFBP1 as associated with the prognosis of stomach adenocarcinoma. In Medicine, 102, e33346. doi:10.1097/MD.0000000000033346. https://pubmed.ncbi.nlm.nih.gov/37000073/
9. Wang, Chuanling, Tang, Yi, Zhang, ShuXian, Yang, Lian, Wang, YaLan. 2024. Histone MARylation regulates lipid metabolism in colorectal cancer by promoting IGFBP1 methylation. In Experimental cell research, 443, 114308. doi:10.1016/j.yexcr.2024.114308. https://pubmed.ncbi.nlm.nih.gov/39490887/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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