C57BL/6JCya-Stard3em1flox/Cya
Common Name
Stard3-flox
Product ID
S-CKO-12501
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-59045-Stard3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Stard3-flox Mouse (Catalog S-CKO-12501) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Stard3-flox
Strain ID
CKOCMP-59045-Stard3-B6J-VA
Gene Name
Product ID
S-CKO-12501
Gene Alias
es64, Mln64
Background
C57BL/6JCya
Gene Full Name
START domain containing 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 11 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000018311
NCBI Transcript ID
NM_021547
Target Region
Exon 6~13
Size of Effective Region
~3.2 kb
Overview of Gene Research
STARD3, also known as StAR-related lipid transfer domain-3, is a sterol-binding protein. It is a member of the START family involved in lipid transfer, especially crucial for non-vesicular cholesterol transportation within the cell. It plays a role in creating endoplasmic reticulum (ER)-endosome contact sites and is involved in the cholesterol metabolic pathway, which is important as cancer cells have an increased demand for cholesterol [1,2,3,6].
In breast cancer, STARD3 is correlated with HER2 amplification as it is located on the same chromosome region. In a study of HER2-positive breast cancer patients, STARD3 protein expression was associated with pathological complete response after neoadjuvant systemic treatment, suggesting it could be a biomarker for predicting treatment response [4].
In diabetes-induced podocyte injury, upregulation of STARD3 leads to increased cholesterol transport from late endosomal/lysosomal to mitochondria, causing mitochondrial cholesterol accumulation and cell injury. Downregulating STARD3 expression alleviates this injury, indicating its potential as a therapeutic target for diabetic kidney disease [5].
In conclusion, STARD3 is essential for cholesterol transport within cells and plays a significant role in diseases such as breast cancer and diabetic kidney disease. Research on STARD3 using in vivo models helps in understanding its function in these disease conditions, providing potential new directions for biomarker discovery and therapeutic strategies.
References：
1. Asif, Kanwal, Memeo, Lorenzo, Palazzolo, Stefano, Tuccinardi, Tiziano, Rizzolio, Flavio. 2021. STARD3: A Prospective Target for Cancer Therapy. In Cancers, 13, . doi:10.3390/cancers13184693. https://pubmed.ncbi.nlm.nih.gov/34572920/
2. Wilhelm, Léa P, Tomasetto, Catherine, Alpy, Fabien. . Touché! STARD3 and STARD3NL tether the ER to endosomes. In Biochemical Society transactions, 44, 493-8. doi:10.1042/BST20150269. https://pubmed.ncbi.nlm.nih.gov/27068960/
3. Korucu, Almila Nazli, Inandiklioglu, Nihal. 2024. Is STARD3 A New Biomarker for Breast Cancer? In European journal of breast health, 20, 89-93. doi:10.4274/ejbh.galenos.2024.2024-1-7. https://pubmed.ncbi.nlm.nih.gov/38571685/
4. Lodi, Massimo, Voilquin, Laetitia, Alpy, Fabien, Chenard, Marie-Pierrette, Tomasetto, Catherine-Laure. 2023. STARD3: A New Biomarker in HER2-Positive Breast Cancer. In Cancers, 15, . doi:10.3390/cancers15020362. https://pubmed.ncbi.nlm.nih.gov/36672312/
5. Hu, Jijia, Zhu, Zijing, Zhang, Zongwei, Hu, Hongtu, Yang, Qian. 2024. Blockade of STARD3-mediated cholesterol transport alleviates diabetes-induced podocyte injury by reducing mitochondrial cholesterol accumulation. In Life sciences, 349, 122722. doi:10.1016/j.lfs.2024.122722. https://pubmed.ncbi.nlm.nih.gov/38754814/
6. Wilhelm, Léa P, Wendling, Corinne, Védie, Benoît, Drin, Guillaume, Alpy, Fabien. 2017. STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. In The EMBO journal, 36, 1412-1433. doi:10.15252/embj.201695917. https://pubmed.ncbi.nlm.nih.gov/28377464/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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