C57BL/6JCya-Ticam1em1/Cya
Common Name
Ticam1-KO
Product ID
S-KO-00465
Backgroud
C57BL/6JCya
Strain ID
KOCMP-106759-Ticam1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ticam1-KO Mouse (Catalog S-KO-00465) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ticam1-KO
Strain ID
KOCMP-106759-Ticam1-B6J-VA
Gene Name
Product ID
S-KO-00465
Gene Alias
TRIF, TICAM-1
Background
C57BL/6JCya
Gene Full Name
TIR domain containing adaptor molecule 1
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 17 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000058136
NCBI Transcript ID
NM_174989
Target Region
Exon 2
Size of Effective Region
~2.6 kb
Overview of Gene Research
Ticam1, also known as Toll-like receptor adaptor molecule 1, is a key coding gene involved in immune and inflammation responses to malignant cells. It is an essential adaptor protein in Toll-like receptor (TLR) signaling pathways, especially in the TLR3-and TLR4-mediated MyD88-independent pathway. TLRs play a crucial role in activating innate immunity by recognizing microbial components, and Ticam1 contributes to the specificity of TLR signaling [2].
In Wilms tumor (WT), Ticam1 was found to be downregulated in patients with worse prognosis and more advanced clinical stages. Low expression of Ticam1 led to less immune cell infiltration, fewer protective immune cells, and more antitumor immune cells, indicating its significant impact on the prognosis, progression, and immune infiltration of WT [1]. In children, Ticam1 gene polymorphisms were associated with community-acquired pneumonia (CAP). For example, the CC genotype of rs11466711T/C locus reduced the risk of childhood CAP, while certain genotypes and haplotypes were related to CRP level and sepsis in childhood CAP [3].
In conclusion, Ticam1 is vital in immune-related signaling pathways. Its role in diseases like Wilms tumor and childhood CAP is significant, as demonstrated through studies on gene expression levels and polymorphisms. These findings contribute to our understanding of disease mechanisms and may potentially offer new insights for diagnosis and treatment in these disease areas.
References:
1. Lu, Zhiyi, Sun, Fengyin. 2022. Downregulated TICAM1 is a prognostic biomarker and associated with immune tolerance of Wilms tumor patients. In BMC medical genomics, 15, 174. doi:10.1186/s12920-022-01326-5. https://pubmed.ncbi.nlm.nih.gov/35933370/
2. Takeda, Kiyoshi, Akira, Shizuo. . TLR signaling pathways. In Seminars in immunology, 16, 3-9. doi:. https://pubmed.ncbi.nlm.nih.gov/14751757/
3. Yang, Yong, Yang, Suiyu, Chen, Zongbo, Liu, Li. 2020. Correlation between TICAM1 gene polymorphisms and community-acquired pneumonia in children. In Journal of biochemical and molecular toxicology, 34, e22503. doi:10.1002/jbt.22503. https://pubmed.ncbi.nlm.nih.gov/32243044/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
