C57BL/6JCya-Il1rl1em1/Cya
Common Name
Il1rl1-KO
Product ID
S-KO-03009
Backgroud
C57BL/6JCya
Strain ID
KOCMP-17082-Il1rl1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Il1rl1-KO Mouse (Catalog S-KO-03009) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Il1rl1-KO
Strain ID
KOCMP-17082-Il1rl1-B6J-VA
Gene Name
Product ID
S-KO-03009
Gene Alias
T1, St2, DER4, Ly84, ST2L, Fit-1, T1/ST2, St2-rs1
Background
C57BL/6JCya
Gene Full Name
interleukin 1 receptor-like 1
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 1 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000097772
NCBI Transcript ID
NM_001025602
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Overview of Gene Research
IL1RL1, also known as ST2 receptor, is a crucial cytokine receptor. It binds to interleukin-33 (IL-33), and this interaction is involved in multiple immune-related pathways. The IL-33/IL1RL1 signaling pathway plays a significant role in immune responses, especially in type-2, type-1, and regulatory immune responses, and is associated with various diseases such as allergic, fibrotic, infectious, and chronic inflammatory diseases [2].
In acute myeloid leukemia (AML) models, IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells. IL-33 treatment, through binding to IL1RL1, increased the serial replating ability and expression of pro-survival proteins in vitro, and IL1RL1+ cells survived chemotherapy better in vivo [3]. Further study in the human inv(16) AML cell line ME-1 showed that IL-33/IL1RL1 axis decreased drug sensitivity, increased the expression of IL-4 and IL-6, activated p38 MAPK and NF-κB, and decreased apoptosis by phosphorylating p38 MAPK [4]. In the tumor microenvironment, IL1RL1 signaling in regulatory T (Treg) cells dampened the antitumor activity of both IL-33 and PD-1 blockade. The amphiregulin (AREG)-epidermal growth factor receptor (EGFR) axis mediated cross-talk between IL1RL1+ Treg cells and cancer-associated fibroblasts (CAFs), enabling Treg cells to promote a profibrotic and immunosuppressive functional state of CAFs [1].
In conclusion, IL1RL1 is a key cytokine receptor involved in multiple biological processes and diseases. Its role in promoting cell survival in AML and impeding antitumor immunity in the tumor microenvironment has been revealed through model-based research. These findings provide insights into potential therapeutic targets for AML and cancer immunotherapy.
References:
1. Sun, Runzi, Zhao, Hongyu, Gao, David Shihong, Chen, Kong, Lu, Binfeng. 2023. Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity. In Science advances, 9, eadd7399. doi:10.1126/sciadv.add7399. https://pubmed.ncbi.nlm.nih.gov/37611111/
2. Cayrol, Corinne, Girard, Jean-Philippe. . Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. In Immunological reviews, 281, 154-168. doi:10.1111/imr.12619. https://pubmed.ncbi.nlm.nih.gov/29247993/
3. Wang, Yiqian, Richter, Lisa, Becker, Michelle, Amador, Catalina, Hyde, R Katherine. 2019. IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival. In Scientific reports, 9, 1729. doi:10.1038/s41598-018-38408-3. https://pubmed.ncbi.nlm.nih.gov/30742053/
4. Wang, Yiqian, Luo, Huanmin, Wei, Mengyi, Hyde, R Katherine, Gong, Qing. 2020. IL-33/IL1RL1 axis regulates cell survival through the p38 MAPK pathway in acute myeloid leukemia. In Leukemia research, 96, 106409. doi:10.1016/j.leukres.2020.106409. https://pubmed.ncbi.nlm.nih.gov/32652328/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
