C57BL/6JCya-Dyrk3em1/Cya
Common Name
Dyrk3-KO
Product ID
S-KO-05974
Backgroud
C57BL/6JCya
Strain ID
KOCMP-226419-Dyrk3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Dyrk3-KO Mouse (Catalog S-KO-05974) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Dyrk3-KO
Strain ID
KOCMP-226419-Dyrk3-B6J-VA
Gene Name
Product ID
S-KO-05974
Gene Alias
--
Background
C57BL/6JCya
Gene Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 1 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000016670
NCBI Transcript ID
NM_145508
Target Region
Exon 1~3
Size of Effective Region
~9.5 kb
Overview of Gene Research
DYRK3, short for dual-specificity tyrosine-phosphorylation-regulated kinase 3, is a key kinase involved in multiple biological processes. It belongs to the DYRK family and plays essential roles in processes such as secretory trafficking, where it maintains the liquid-like state of ER exit sites (ERESs), thus enabling directional membrane traffic in eukaryotic cells [1]. It is also associated with pathways related to cell growth, differentiation, and stress response. Genetic models, like knockout mice, have been valuable in studying its functions.
DYRK3 knockout (KO) mouse experiments show that in anemia, DYRK3 -/- mice exhibit enhanced erythropoiesis, indicating that DYRK3 attenuates red cell production selectively during anemia [4]. In glioblastoma, knockdown of DYRK3 inhibits mitochondrial fission, leading to increased oxidative phosphorylation and reduced glycolysis, and impairs cell migration and invasion, suggesting its role in promoting glioblastoma malignancy [3]. In oral squamous cell carcinoma (OSCC), inhibition of DYRK3 can combat radiotherapy resistance, highlighting the role of the DYRK3/PAICS axis in OSCC radiotherapy resistance pathways [2].
In conclusion, DYRK3 is crucial for regulating multiple biological processes. KO mouse models have revealed its significant roles in diseases such as anemia, glioblastoma, and OSCC. Understanding DYRK3 functions provides insights into disease mechanisms and may offer potential therapeutic targets for these diseases.
References:
1. Gallo, Raffaella, Rai, Arpan Kumar, McIntyre, Alexa B R, Meyer, Katrina, Pelkmans, Lucas. 2023. DYRK3 enables secretory trafficking by maintaining the liquid-like state of ER exit sites. In Developmental cell, 58, 1880-1897.e11. doi:10.1016/j.devcel.2023.08.005. https://pubmed.ncbi.nlm.nih.gov/37643612/
2. Huang, Chin-Sheng, Hsieh, Ming-Shou, Yadav, Vijesh Kumar, Yeh, Chi-Tai, Huang, Mao-Suan. 2023. PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma. In International journal of molecular sciences, 24, . doi:10.3390/ijms242417346. https://pubmed.ncbi.nlm.nih.gov/38139175/
3. Kim, Kyeongmin, Lee, Sungmin, Kang, Hyunkoo, Youn, HyeSook, Youn, BuHyun. 2021. Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function. In International journal of molecular sciences, 22, . doi:10.3390/ijms22062982. https://pubmed.ncbi.nlm.nih.gov/33804169/
4. Bogacheva, Olga, Bogachev, Oleg, Menon, Madhu, Erickson-Miller, Connie L, Wojchowski, Don M. 2008. DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. In The Journal of biological chemistry, 283, 36665-75. doi:10.1074/jbc.M807844200. https://pubmed.ncbi.nlm.nih.gov/18854306/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
