C57BL/6JCya-Fsd1em1/Cya
Common Name
Fsd1-KO
Product ID
S-KO-07165
Backgroud
C57BL/6JCya
Strain ID
KOCMP-240121-Fsd1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Fsd1-KO Mouse (Catalog S-KO-07165) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Fsd1-KO
Strain ID
KOCMP-240121-Fsd1-B6J-VA
Gene Name
Product ID
S-KO-07165
Gene Alias
--
Background
C57BL/6JCya
Gene Full Name
fibronectin type 3 and SPRY domain-containing protein
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 17 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000011733
NCBI Transcript ID
NM_183178
Target Region
Exon 4~7
Size of Effective Region
~3.4 kb
Overview of Gene Research
Fsd1, or iron superoxide dismutase 1, is an enzyme with diverse functions. In plants like Arabidopsis, it acts as an antioxidant enzyme in plastids, cytoplasm, and nuclei, playing roles in osmoprotection and response to oxidative stress [1,4]. In mammals, it has functions related to cell structure and development. For example, in glioblastoma, it inhibits diffuse infiltration through regulating microtubule deacetylation [2].
In Arabidopsis, fsd1 mutants show reduced capacity to decompose superoxide at low Cu2+ concentrations, and prolonged exposure to methyl viologen leads to reduced ascorbate levels and higher protein carbonylation compared to the wild type [1]. These mutants also have higher levels of chloroplastic proteases, indicating altered protein turnover in chloroplasts [1]. In glioblastoma, decreased Fsd1 expression in tissues correlates with microtubule deacetylation and poor clinical outcomes, and increased Fsd1 expression or interference with its phosphorylation can suppress invasion of glioblastoma stem cells [2]. In vertebrates, knockdown of Fsd1 causes defective ciliogenesis and affects embryonic development [3].
In summary, Fsd1 is crucial for maintaining redox homeostasis in plants under oxidative stress and has important implications in controlling glioblastoma cell invasion and ciliogenesis in animals. The study of Fsd1 using gene knockout models in these systems has provided valuable insights into its functions in specific biological processes and disease conditions.
References:
1. Melicher, Pavol, Dvořák, Petr, Krasylenko, Yuliya, Šamaj, Jozef, Takáč, Tomáš. 2022. Arabidopsis Iron Superoxide Dismutase FSD1 Protects Against Methyl Viologen-Induced Oxidative Stress in a Copper-Dependent Manner. In Frontiers in plant science, 13, 823561. doi:10.3389/fpls.2022.823561. https://pubmed.ncbi.nlm.nih.gov/35360337/
2. Xiao, Dake, Ran, Haowen, Chen, Lishu, Li, Ailing, Man, Jianghong. 2025. FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation. In Science China. Life sciences, 68, 673-688. doi:10.1007/s11427-024-2616-7. https://pubmed.ncbi.nlm.nih.gov/39808222/
3. Tu, Hai-Qing, Qin, Xuan-He, Liu, Zhi-Bin, Zhang, Xue-Min, Li, Hui-Yan. 2018. Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. In Nature communications, 9, 5277. doi:10.1038/s41467-018-07664-2. https://pubmed.ncbi.nlm.nih.gov/30538248/
4. Dvořák, Petr, Krasylenko, Yuliya, Ovečka, Miroslav, Šamaj, Jozef, Takáč, Tomáš. 2020. In vivo light-sheet microscopy resolves localisation patterns of FSD1, a superoxide dismutase with function in root development and osmoprotection. In Plant, cell & environment, 44, 68-87. doi:10.1111/pce.13894. https://pubmed.ncbi.nlm.nih.gov/32974958/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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