C57BL/6JCya-Bpifa3em1/Cya
Common Name
Bpifa3-KO
Product ID
S-KO-16917
Backgroud
C57BL/6JCya
Strain ID
KOCMP-73388-Bpifa3-B6J-VB
Status
When using this mouse strain in a publication, please cite “Bpifa3-KO Mouse (Catalog S-KO-16917) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Bpifa3-KO
Strain ID
KOCMP-73388-Bpifa3-B6J-VB
Gene Name
Product ID
S-KO-16917
Gene Alias
Splunc3, 1700058C13Rik
Background
C57BL/6JCya
Gene Full Name
BPI fold containing family A, member 3
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 2 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000028984
NCBI Transcript ID
NM_028528
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Overview of Gene Research
Bpifa3, with currently no widely-known common aliases, has been associated with certain biological functions relevant to disease susceptibility. While its exact core function is not fully elaborated in the provided references, it is part of the BPIFA gene cluster on chromosome 20q11.21. Pathway analysis in one study connected top candidates to the TGFβ pathway, suggesting Bpifa3 may be involved in this pathway [2]. Understanding Bpifa3 through genetic models like KO or CKO mouse models could potentially shed more light on its in-vivo functions.
In a genome-wide association study for otitis media susceptibility in childhood, Bpifa3 in the BPIFA gene cluster was among the top hits in a gene-based analysis in VEGAS (P(Gene) = 2 × 10(-5)), indicating its possible role in determining susceptibility to otitis media [2]. In a systematic review and meta-analysis of skin ageing, Bpifa3 was one of the loci associated with skin ageing (odds ratio 1.859, 95% confidence interval [1.567, 2.151]), suggesting it may play a part in the genetic mechanisms of skin ageing [1].
In conclusion, Bpifa3 appears to be associated with otitis media susceptibility and skin ageing. Genetic studies, potentially including KO/CKO mouse models in the future, could further clarify its function in these disease areas, enhancing our understanding of the underlying biological processes related to otitis media and skin ageing.
References:
1. Wong, Chloe, Ng, Jun Yan, Sio, Yang Yie, Chew, Fook Tim. 2025. Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes. In Journal of physiological anthropology, 44, 4. doi:10.1186/s40101-025-00384-9. https://pubmed.ncbi.nlm.nih.gov/39923055/
2. Rye, Marie S, Warrington, Nicole M, Scaman, Elizabeth S H, Blackwell, Jenefer M, Jamieson, Sarra E. 2012. Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood. In PloS one, 7, e48215. doi:10.1371/journal.pone.0048215. https://pubmed.ncbi.nlm.nih.gov/23133572/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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