C57BL/6JCya-Fanccem1/Cya
Common Name
Fancc-KO
Product ID
S-KO-17921
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14088-Fancc-B6J-VA
Status
When using this mouse strain in a publication, please cite “Fancc-KO Mouse (Catalog S-KO-17921) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Fancc-KO
Strain ID
KOCMP-14088-Fancc-B6J-VA
Gene Name
Product ID
S-KO-17921
Gene Alias
Facc
Background
C57BL/6JCya
Gene Full Name
Fanconi anemia, complementation group C
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 13 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000073029
NCBI Transcript ID
NM_001042673
Target Region
Exon 5~6
Size of Effective Region
~1.5 kb
Overview of Gene Research
Fancc, a gene within the Fanconi anemia (FA) gene family, plays crucial roles in DNA damage signaling, oxygen radical metabolism, signal transduction, transcriptional regulation, and apoptosis [3]. It is part of the FA/BRCA repair pathway, which is vital for maintaining genomic stability [4]. Genetic models, such as gene knockout (KO) mouse models, are valuable tools for studying Fancc's functions.
In meiotic studies, Fancc was identified as a new anti-crossover (anti-CO) gene in Arabidopsis thaliana, and its physical interaction with Fance-Fancf is conserved from vertebrates to plants. Mutations in Fancc, along with Fance or Fancf, can partially rescue CO-defective mutants, especially in female meiosis. Loss of function of these genes leads to synthetic meiotic catastrophe with the pro-CO factor MUS81, suggesting that Fancc, together with Fance and Fancf, regulates meiotic recombination [1].
In traumatic spinal cord injury (SCI) mouse models, FANCC deficiency was found to mediate microglial pyroptosis, secondary neuronal apoptosis, and neurological damage. Overexpression of FANCC suppressed microglial pyroptosis via inhibiting p38/NLRP3 expression, reducing neuronal apoptosis, while knockdown of FANCC had the opposite effect [2].
In conclusion, Fancc is essential for regulating meiotic recombination and has a significant impact on processes related to SCI. Studies using KO mouse models have revealed its role in maintaining genomic stability during meiosis and in modulating neuroinflammatory responses after SCI, providing insights into potential therapeutic targets for related diseases.
References：
1. Singh, Dipesh Kumar, Gamboa, Rigel Salinas, Singh, Avinash Kumar, Crismani, Wayne, Mercier, Raphael. . The FANCC-FANCE-FANCF complex is evolutionarily conserved and regulates meiotic recombination. In Nucleic acids research, 51, 2516-2528. doi:10.1093/nar/gkac1244. https://pubmed.ncbi.nlm.nih.gov/36652992/
2. Xia, Mingjie, Li, Xinyu, Ye, Suhui, Qian, Zhanyang, Yang, Lei. 2022. FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion. In Cell & bioscience, 12, 82. doi:10.1186/s13578-022-00816-4. https://pubmed.ncbi.nlm.nih.gov/35659106/
3. Huang, FengFei, Ben Aissa, Manel, Lévesque, Georges, Carreau, Madeleine. 2018. FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis. In BMC research notes, 11, 662. doi:10.1186/s13104-018-3763-1. https://pubmed.ncbi.nlm.nih.gov/30213274/
4. García-de Teresa, Benilde, Frias, Sara, Molina, Bertha, Olaya-Vargas, Alberto, Torres, Leda. 2019. FANCC Dutch founder mutation in a Mennonite family from Tamaulipas, México. In Molecular genetics & genomic medicine, 7, e710. doi:10.1002/mgg3.710. https://pubmed.ncbi.nlm.nih.gov/31044565/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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