C57BL/6JCya-Agxt2em1/Cya
Common Name
Agxt2-KO
Product ID
S-KO-18960
Backgroud
C57BL/6JCya
Strain ID
KOCMP-268782-Agxt2-B6J-VC
Status
When using this mouse strain in a publication, please cite “Agxt2-KO Mouse (Catalog S-KO-18960) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Agxt2-KO
Strain ID
KOCMP-268782-Agxt2-B6J-VC
Gene Name
Product ID
S-KO-18960
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15 (Mouse)
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Transcript ID
ENSMUST00000022858
NCBI Transcript ID
NM_001031851
Target Region
Exon 5
Size of Effective Region
~0.1 kb
Overview of Gene Research
Agxt2, or alanine-glyoxylate aminotransferase 2, is a multifunctional mitochondrial aminotransferase first identified in 1978. It is involved in multiple metabolic pathways, with substrates and products that play roles in cardiovascular, renal, neurological, and hematological processes. It has been shown to be involved in the metabolism of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), which are crucial in cardiovascular disease development and prediction of cardiovascular events [1,2].
In various studies, Agxt2 has been associated with different disease conditions. In cats, genetic variants of Agxt2 are related to 2-oxoarginine levels and calcium oxalate stone formation, with certain variants responding differently to dietary interventions [4]. In humans, Agxt2 SNP rs37369 is a risk factor for diabetes mellitus, and its polymorphism can affect the renal function in chronic heart failure patients, especially in smokers [3,5]. Also, missense variants of Agxt2 may be related to vascular diseases like hypertension and diabetes mellitus via the nitric oxide system, and the gene's SNPs are associated with depressive symptoms [6,7].
In conclusion, Agxt2 is a key enzyme in multiple metabolic pathways. Research on its genetic variants and functions using human population studies has revealed its importance in various disease areas such as diabetes, cardiovascular and renal diseases, as well as in mental health conditions like depressive symptoms. These findings contribute to a better understanding of the underlying disease mechanisms and may potentially lead to new diagnostic and therapeutic strategies.
References：
1. Rodionov, Roman N, Jarzebska, Natalia, Weiss, Norbert, Lentz, Steven R. 2014. AGXT2: a promiscuous aminotransferase. In Trends in pharmacological sciences, 35, 575-82. doi:10.1016/j.tips.2014.09.005. https://pubmed.ncbi.nlm.nih.gov/25294000/
2. Hu, Xiao-Lei, Li, Mu-Peng, Song, Pei-Yuan, Tang, Jie, Chen, Xiao-Ping. 2017. AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems. In Journal of molecular and cellular cardiology, 113, 33-38. doi:10.1016/j.yjmcc.2017.09.010. https://pubmed.ncbi.nlm.nih.gov/28970090/
3. Kumon, Hiroshi, Miyake, Yoshihiro, Yoshino, Yuta, Kawamoto, Ryuichi, Ueno, Shu-Ichi. 2022. Functional AGXT2 SNP rs37369 Variant Is a Risk Factor for Diabetes Mellitus: Baseline Data From the Aidai Cohort Study in Japan. In Canadian journal of diabetes, 46, 829-834. doi:10.1016/j.jcjd.2022.06.004. https://pubmed.ncbi.nlm.nih.gov/35961823/
4. Hall, Jean A, Panickar, Kiran S, Brockman, Jeffrey A, Jewell, Dennis E. 2022. Cats with Genetic Variants of AGXT2 Respond Differently to a Dietary Intervention Known to Reduce the Risk of Calcium Oxalate Stone Formation. In Genes, 13, . doi:10.3390/genes13050791. https://pubmed.ncbi.nlm.nih.gov/35627178/
5. Hu, Xiao-Lei, Zeng, Wen-Jing, Li, Mu-Peng, Zhang, Ke, Chen, Xiao-Ping. 2017. AGXT2 rs37369 polymorphism predicts the renal function in patients with chronic heart failure. In Gene, 637, 145-151. doi:10.1016/j.gene.2017.09.038. https://pubmed.ncbi.nlm.nih.gov/28942034/
6. Yoshino, Yuta, Kumon, Hiroshi, Mori, Takaaki, Iga, Jun-Ichi, Ueno, Shu-Ichi. 2021. Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method. In BMC genomics, 22, 287. doi:10.1186/s12864-021-07612-3. https://pubmed.ncbi.nlm.nih.gov/33879046/
7. Kumon, Hiroshi, Miyake, Yoshihiro, Yoshino, Yuta, Kawamoto, Ryuichi, Ueno, Shu-Ichi. 2024. Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan. In Journal of neural transmission (Vienna, Austria : 1996), 131, 267-274. doi:10.1007/s00702-024-02742-w. https://pubmed.ncbi.nlm.nih.gov/38261033/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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