C57BL/6JCya-Wnt16em1/Cya
Common Name
Wnt16-KO
Product ID
S-KO-20395
Backgroud
C57BL/6JCya
Strain ID
KOCMP-93735-Wnt16-B6J-VB
Status
When using this mouse strain in a publication, please cite “Wnt16-KO Mouse (Catalog S-KO-20395) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Wnt16-KO
Strain ID
KOCMP-93735-Wnt16-B6J-VB
Gene Name
Product ID
S-KO-20395
Gene Alias
E130309I19Rik
Background
C57BL/6JCya
Gene Full Name
wingless-type MMTV integration site family, member 16
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 6 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000031681
NCBI Transcript ID
NM_053116
Target Region
Exon 3
Size of Effective Region
~1.6 kb
Overview of Gene Research
Wnt16 is a member of the Wnt family of secreted cysteine-rich glycoproteins. It is involved in joint development, skeletal homeostasis, and has been associated with the Wnt signaling pathway. Wnt16 is of great biological importance as it is strongly associated with bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk [1,2].
In KO/CKO mouse models, Wnt16 deficiency has shown various effects. In bone, it causes postnatal bone loss, reduces systolic blood pressure, and leads to abnormal vascular smooth muscle (VSM) mitochondrial morphology with reduced mitochondrial respiration [3]. In chondrocytes, Wnt16 deficiency exaggerates osteoarthritis (OA) progression [4]. In zebrafish, wnt16 is required for spine and muscle morphogenesis, affecting the morphogenesis of these tissues throughout the lifespan [5].
In conclusion, Wnt16 plays a crucial role in bone and joint-related biological processes. Studies using KO/CKO mouse models and zebrafish have revealed its significance in maintaining bone mass, regulating OA progression, and influencing muscle and spine morphogenesis. These findings highlight its potential as a therapeutic target for skeletal diseases and OA [1,4].
References：
1. Ye, Xiaoping, Liu, Xianwen. 2022. Wnt16 signaling in bone homeostasis and osteoarthristis. In Frontiers in endocrinology, 13, 1095711. doi:10.3389/fendo.2022.1095711. https://pubmed.ncbi.nlm.nih.gov/36619549/
2. Gómez, Arianna Ericka, Addish, Sumaya, Alvarado, Kurtis, Tang, W Joyce, Kwon, Ronald Young. 2023. Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus. In Current osteoporosis reports, 21, 173-183. doi:10.1007/s11914-023-00783-w. https://pubmed.ncbi.nlm.nih.gov/36943599/
3. Behrmann, Abraham, Zhong, Dalian, Li, Li, Kozlitina, Julia, Towler, Dwight A. . Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice. In Endocrinology, 165, . doi:10.1210/endocr/bqad192. https://pubmed.ncbi.nlm.nih.gov/38123514/
4. Tong, Wenxue, Zeng, Yelin, Chow, Dick Ho Kiu, Qin, Ling, Mak, Kingston King-Lun. 2019. Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade. In Annals of the rheumatic diseases, 78, 551-561. doi:10.1136/annrheumdis-2018-214200. https://pubmed.ncbi.nlm.nih.gov/30745310/
5. Watson, Claire J, Tang, W Joyce, Rojas, Maria F, Hsu, Yi-Hsiang, Kwon, Ronald Young. 2022. wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. In PLoS genetics, 18, e1010496. doi:10.1371/journal.pgen.1010496. https://pubmed.ncbi.nlm.nih.gov/36346812/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
