The Taconic-Cyagen Alliance (The Alliance) has capabilities to ensure the success of any project. The Alliance provides specially-tailored products and services for the academic and non-profit markets. Together, we have streamlined the model design process to provide the academic market access to premium model generation and colony management services backed by comprehensive capabilities and cutting-edge, fully licensed technologies with competitive pricing. As partners, Taconic and Cyagen leverage the power of our complementary approaches to provide customers with the best and most competitive solutions for their projects.

 

The Complete Solution for Model Generation

The Alliance redefines what non-profit researchers can expect from a custom model generation service provider and partner. What this means for you is a full catalog of cost effective, guaranteed model generation services, and access to accelerated timelines and downstream comprehensive breeding services. Multiple delivery options that allow for direct import into your facility mitigate quarantine and cost concerns associated with traditional importation*.

 

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Model Generation Benefits of The Alliance

Integration from Start to Finish

Combining Efficiency, Technology, and Logistics to Redefine Model Generation

  • Fast Project Scoping
    The Alliance can leverage AI-powered processes to generate quotes for your project as fast as 2 business days.
  • Cost Effective, Guaranteed Model Generation
    Each project with the alliance comes with a guaranteed deliverable to facilitate discovery. We are also aware of the budgetary constraints non-profit researchers may face and aim to maximize the value of each project.
  • Comprehensive Capabilities
    The Alliance provides researchers with access to a comprehensive toolkit of technologies, including but not limited to: CRISPR/Cas9, transgenic technology, PiggyBac, and embryonic stem cell (ESC)-based homologous recombination (HR).
  • Flexible Delivery Options
    With a variety of delivery and rederivation options, The Alliance can deliver your model to your vivarium without the need for quarantine no matter your vivarium's restrictions*.
  • Access to Accelerated Timelines
    With the ability to rapidly generate age matched cohorts of 20-40+ animals at any Taconic health standard, the Alliance can drastically reduce time spent on conventional breeding strategies.

* Please check and confirm with your vivarium and veterinarian to confirm which delivery method allows for importation without quarantine into your facilities.

 

Turn-key Experience from Design to Delivery

Seamless Integration Meets Flexible Solutions for Optimizing Your Research

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You first meet with your Taconic partner to present your ideas for a genetically engineered model. We then return with a complete design and proposal. Taconic’s model design specialists are also available for consultation. Once we are aligned on the best solution, we are ready when you are to move forward with your project.
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Your model is generated at Cyagen’s facilities with project updates being provided directly by your Cyagen project manager. Your Cyagen project manager will serve as your point of contact ensuring you have direct communication during model generation.
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Once your model is completed, your model will ship from Cyagen to Taconic’s facilities where it will then undergo one of three customer-selected options, RapidRELAY, RapidCHECK or RapidEXPANSION, depending on the requirements of your institutional vivarium. Your Cyagen project manager will introduce you to Taconic’s logistic team who will assist in the final coordination of shipping your model.
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Delivery Options
Option A: RapidRELAY projects, your animals are shipped directly to your vivarium without additional testing, with animals carrying Cyagen’s Select Pathogen Free (SPF) health status.
Option B: RapidCHECK projects, your animals undergo validation health testing at Taconic thereby verifying their SPF status from Cyagen, and allowing for importation without quarantine*.
Option C: RapidEXPANSION projects, your animals are rederived to one of Taconic’s International Health Monitoring System (IHMS) health standards using Taconic’s RapidEXPANSION technology, reducing time to cohort and guaranteeing a commercial-grade health standard.

 

Alliance Import and Delivery Advantages – Health Standards to Bypass Quarantine*

The Alliance removes concerns with importing your model into your home facility by providing a variety of options for exclusion, tolerance, and testing of various pathogens for your project with RapidRELAY™, RapidCHECK™, and RapidEXPANSION™. We understand the challenges that non-profit researchers can experience when importing models into their facilities and have designed this suite of delivery options to address common barriers to importation. Depending on the requirements of your facility, one option may be more appropriate to ensure your animals are delivered without the need or added costs of quarantine.

* Please check and confirm with your vivarium and veterinarian to confirm which delivery method allows for importation without quarantine into your facilities.

 

Alliance Model Generation Capabilities

Leveraging the Best Technology for Each Project

The Taconic-Cyagen Model Generation Alliance (The Alliance) leverages Cyagen’s complete catalog of methodologies for generating novel mouse and rat models so that your research is not limited by available technologies. Whether your studies require the modification of an existing model or de novo generation of a complex or humanized model, The Alliance can match each project with the best methodology for success.

We can create any custom mouse or rat model for your project, from simple knockout (KO) and point mutation constructs, all the way through to more complicated constructs, such as conditional knockin (cKI) or humanization models.

Custom Mouse & Rat Model Generation
Knockouts (KO) Constitutive knockouts can be quickly generated utilizing Cyagen’s TurboKnockout® embryonic stem cell (ESC) based technology providing ESC based models at timelines comparable to CRISPR based models. CRISPR is also available, with AI-based bioinformatic analysis driving identification of the optimal region to target. Conditional Knockouts and Knock-ins (cKO/cKI) Conditional knockouts and knock-ins can also be quickly generated using TurboKnockout®. With a germline guarantee and self-deleting selection cassette, TurboKnockout® accelerates traditional ESC based model generation. Point Mutation Knock-ins Point mutations can be quickly generated via CRISPR or Cyagen’s accelerated ESC based method, TurboKnockout®, enabling more complex point mutations and/or genetic modifications.
Large-fragment Knock-ins (LFKI) Rosa26 and other safe harbor loci can be targeted for large fragment knock-ins (LFKI) using a variety of methodologies to ensure your studies are not limited by technology or capability. With the ability to perform LFKI at any locus, the only limit to your studies is your ingenuity. Humanization Humanized models have been widely used in studies of human gene function, immune-oncology therapeutics, infectious disease pathology, and preclinical drug evaluation in the field of biomedicine. TurboKnockout® enables more efficient and stable gene integration for the development of humanized mouse models. Transgenics With the capability to generate both traditional and PiggyBac-based transgenics, The Alliance can provide your research with cost-effective transgenic models with the ability to avoid gene silencing with single- copy-per-integration-site, and no loss of transgene sequence when using PiggyBac.
Multiple Donor Strains Available ♦ Mouse: C57BL/6, FVB, BALB/c
♦ Rat: Sprague-Dawley (SD), Wistar, F344, Long evans, Brown Norway

 

Partner with Us for Your Next Project

With access to Taconic’s expertise, quality, and flexibility, now combined with Cyagen’s speed, efficiency, and economical business model, our team will guide you through the process to the best technical solution, service level, and deliverable for your study.

To learn how The Alliance can get to work on your research, request a consultation for custom model design today. Tell us about your research and goals, timeline, and budget, and let our experts partner with you on your next study.