This strain is an Il10 gene knockout (Il10 KO) mouse, in which the Il10 gene homologous to the human IL10 gene has been knocked out in mice using gene editing technology. Homozygous Il10-KO mice do not produce the anti-inflammatory cytokine IL-10 and can survive and reproduce under specific pathogen-free (SPF) conditions. This strain is maintained in a high-standard SPF environment in Cyagen facilities, and its phenotype differs from that of Il10 knockout mice raised in conventional mouse facilities as reported in the literature. For example, the development of colitis in this model may be slow or non-spontaneous, but the introduction of microbes or fecal microbiota may cause rapid development of colitis in adult animals. Homozygous Il10 KO mice are viable and fertile.