This strain is a Nod2 gene knockout (Nod2 KO) mouse, which uses gene editing technology to knock out the Nod2 gene in mice homologous to the human NOD2 gene. Homozygous Nod2 KO mice are viable and fertile. Research shows that the knockout of the Nod2 gene leads to abnormal morphology and physiology of the immune system in mice and increases their susceptibility to induced colitis. Therefore, the Nod2 KO mouse model can be used for research on inflammatory bowel disease (IBD), Crohn’s disease (CD), irritable bowel syndrome (IBS), and other intestinal or inflammatory diseases as well as other Nod2-related diseases.