Tlr2 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Tlr2 KO
Product ID
C001263
Gene Name
Background
C57BL/6JCya
Gene Alias
Ly105
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
3
Document
Note: When using this mouse strain in a publication, please cite “Tlr2 KO mice (Catalog C001263) were purchased from Cyagen.”
Strain Description
This strain is a Tlr2 gene knockout (Tlr2 KO) mouse, which uses gene editing technology to knock out the Tlr2 gene in mice homologous to the human TLR2 gene. Homozygous Tlr2 KO mice are viable and fertile. It has been reported that the cells of this mouse have defects in TLR2-mediated signal transduction, causing the mouse to exhibit abnormalities in immune responses against bacterial and viral infections. Therefore, Tlr2 KO is often used to study the role of TLR2 in pathogen recognition and the activation of innate immunity.
Application Area
Host responses to bacterial endotoxins such as septic shock
Validation Data