B6-hPDL1-V
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hPDL1-V
Product ID
C001420
Gene Name
Background
C57BL/6NCya
Gene Alias
B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
Classification
Tumor Target Humanized Models,Immune Target Humanized Models
NCBI ID
Phenotype
Chromosome
9
Document
Note: When using this mouse strain in a publication, please cite “B6-hPDL1-V mice (Catalog C001420) were purchased from Cyagen.”
Strain Description
This strain is a humanized model of the mouse Pdl1 gene in which the gene sequence encoding the extracellular domain (immunoglobulin V-like, IgV-like) of mouse PD-L1 protein is replaced with the corresponding human PD-L1 gene sequence. B6-hPDL1-V mice can be used for the research of PD-L1 targeted drug development screening, efficacy and safety evaluation, tumor immunotherapy evaluation, and immune system mechanisms.
Application Area
Development and screening of PD-L1-targeted drugs
Efficacy and safety evaluation of PD-L1-targeted drugs
Evaluation of tumor immunotherapy
Research on the immune system and tumor immune escape mechanisms
Validation Data