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SD-hSCN10A (Nav1.8)
Product ID:
CR006
Background:
SD
Documents:
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Basic Information
Model Name
SD-hSCN10A (Nav1.8)
Product ID
CR006
Gene Name
SCN10A
Background
SD
Gene Alias
PN3; SNS; FEPS2; Nav1.8
Classification
Other Target Humanized Models,Neurological Disease Models
NCBI ID
6336
Phenotype
MGI:108029
Chromosome
3
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Document
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Note
Note: When using this mouse strain in a publication, please cite “SD-hSCN10A (Nav1.8) mice (Catalog CR006) were purchased from Cyagen.”
Strain Description
SD-hSCN10A (Nav1.8) rats are a Scn10a humanized model created by inserting the human SCN10A gene's coding sequence (CDS) and 3'UTR into the rat Scn10a gene. This model can be used for mechanistic studies of acute pain and diabetic peripheral neuropathic pain and the development, screening, and evaluation of analgesic drugs in preclinical research.
Application Area
Area
Mechanisms of acute pain, diabetic peripheral neuropathic pain, and postoperative pain
Area
Preclinical studies on the development, screening, and evaluation of analgesics targeting the Nav1.8 channel
Validation Data
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