Immunodeficient Mice

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Immunodeficient mice refer to mice with defects or deletions in one or more immune components (B cells, T cells, NK cells, etc.) in the immune system due to congenital genetic mutations or artificial methods. With the continuous development of gene editing technology, an increasing number of immunodeficient mouse strains have been developed. Immunodeficient mouse models are widely used in oncology (such as tumor growth, metastasis, anti-tumor drug screening), immunology (such as immune cell development and proliferation mechanism, immune disease occurrence mechanism), epidemiology (such as the pathogenesis of viral/bacterial infectious diseases), stem cell biology (such as human stem cell transplantation) and other research fields. Among these models, severely immunodeficient mice can be efficiently engrafted (due to the lack of T, B and NK immune cells) with human hematopoietic stem cells (HSCs), human peripheral blood mononuclear cells (PBMCs), xenografts derived from human tumor cell lines (CDX), xenografts derived from patient tumor tissues (PDX) or other adult stem cells and tissues, which are widely used in the construction of humanized mice.

Cyagen's drug screening and evaluation mouse model platform can provide you with multiple types of immunodeficiency mouse models such as C-NKG, Rag1 knockout (KO), Rag2 KO, Tcra KO, etc., to assist in the research and development of new drugs.  

Item Number

Model Name

Strain Background

Research and Applications

C001316

NKG

NOD/SCID

Oncology; Immunity; Autoimmune diseases; Immunotherapy vaccines; GvHD/transplantation; Safety assessment and other related studies

C001416

NKG B2m KO

NKG

Graft-versus-host disease (GvHD); The immune system; Hematopoietic system; Blood disease; Cell line-derived xenograft (CDX); Patient-derived xenograft (PDX). (Significantly delayed the onset of GvHD.)

C001498

NKG-H2-Ab1 KO

NKG

Establishment of humanized mouse models for the immune system; research on graft-versus-host disease (GvHD) in xenotransplantation; research on the immune system, hematopoietic system, and blood disorders; xenotransplantation of human cell lines (CDX), patient tumor tissue xenotransplantation (PDX), and drug screening and efficacy evaluation.

C001513

NKG-hIL15

NKG

Severe immunodeficiency second-generation mice, effectively reconstruct NK cells.

C001197

Rag1 KO

C57BL/6N

Research on immune system-related diseases; Establishment of tumor-bearing models; Immune system deficiency; Cancer; Toxicology and other related research

C001324

Rag2 KO

C57BL/6J

Research on immune system-related diseases; Establishment of tumor-bearing models; Immune system deficiency; Cancer; Toxicology and other related research

C001332

Tcra KO

C57BL/6J

Immunology; Inflammation; Autoimmunity research

C001342

B6J-Ighm Ighd-DKO

C57BL/6J

Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research

C001343

BALB/c-Ighm Ighd-DKO

BALB/c

Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research

C001340

B6-Ighm KO

C57BL/6J

Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research

C001341

BALB/c-Ighm KO

BALB/c

Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research

C001344

B6-Ighj KO

C57BL/6J

Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research

C001345

BALB/c-Ighj KO

BALB/c

Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research

C001436

BRG

Balb/c

Oncology; Immunology; Infectious Disease; Stem Cell Biology; and related research.


Cyagen can provide you with a variety of drug evaluation models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.

 

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