Immunodeficient Mice

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Immunodeficient mice are widely used in the construction of humanized mice due to their reduced endogenous immune function – caused by lack of T, B, and/or NK immune cells. The commonly used strains of immunodeficient mice are NOG, NSG, and BRGS. Compared with nude mice, human tissues may be more efficiently xenotransplanted into mice with severe combined immunodeficiency (SCIDs) - including NOD-scid, NOG, and NSG mice.

C-NKG mice are a SCID model independently developed by Cyagen via CRISPR/Cas9-mediated IL2RG gene knockout (KO) on the NOD/Shi-Scid background strain. C-NKG mice lack mature T, B, and NK immune cells, so their complement activity is reduced and macrophages have weakened phagocytotic activity towards human cells. C-NKG mice provide highly efficient transplantation of human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), xenografts (PDX), or adult stem cells and tissues from patients. C-NKG mice exhibit severe combined immunodeficiency (SCID), making it an ideal animal model for tumor, immunity and autoimmunity disease, immunotherapy vaccine, GVHD / transplantation, and safety evaluation research.

Immunodeficient Mice Research and Application
BALB/c nude Mice

Nude mice are ideal hosts for rapidly growing tumor cells because they are hairless and easy to observe and document tumor growth. However, they are not suitable hosts for lymphoma and leukemia studies because they retain B cells and strong NK cell responses.

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Immunodeficient mice lacking both T and B lymphocytes. Multiple immunological defects unique to this model provide an excellent system for reconstitution with human hematopoietic cells, resulting in exceptional models for HIV-1 research and gene therapy.

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C-NKG Mice

C-NKG mice lack mature T, B and NK immune cells, so the complement activity is reduced, and macrophage phagocytosis of human derived cells is weakened. This model can efficiently transplant hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient-derived xenograft (PDX) or adult stem cells and tissues. The C-NKG mouse model is recognized as having high degree of immunodeficiency and has good performance in the study of tumor, immunity, autoimmunity diseases, immunotherapy vaccine, GVHD/transplantation, safety evaluation, etc.

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