B6-Igl KO
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-Igl KO
Product ID
C001550
Gene Name
--
Background
C57BL/6NCya
Gene Alias
--
Classification
Immunodeficient Mouse Models
NCBI ID
--
Phenotype
Chromosome
--
More
--
Document
Note: When using this mouse strain in a publication, please cite “B6-Igl KO mice (Catalog C001550) were purchased from Cyagen.”
Strain Description
The B6-Igl KO mouse is a knockout model targeting the gene segment encoding the λ light chain. Through gene editing, the sequences encoding the V, J, and C regions of the mouse λ light chain (Igl) locus are completely ablated, resulting in the absence of B cells expressing immunoglobulin light chain λ. Consequently, B6-Igl KO mice serve as a valuable tool for investigating B cell development and function, generating κ light chain-only mouse antibodies, elucidating the role of the λ light chain in specific immune responses or autoimmune diseases, and exploring antibody diversity, immune regulatory mechanisms, and potential therapeutic strategies.
Application Area
Investigation of B cell development and function, as well as the analysis of the role of the λ light chain in specific immune responses or autoimmune diseases
Exploration of antibody diversity, immune system regulation mechanisms, and potential therapeutic strategies
Validation Data