Mpo KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Mpo KO
Product ID
C001585
Gene Name
Background
C57BL/6NCya
Gene Alias
mKIAA4033
Classification
Other Disease Models
NCBI ID
Phenotype
Chromosome
11
Document
Note: When using this mouse strain in a publication, please cite “Mpo KO mice (Catalog C001585) were purchased from Cyagen.”
Strain Description
This strain is an Mpo gene knockout (KO) mouse model, constructed by knocking out all protein-coding sequences of the Mpo gene (the homologous gene of human MPO) in mice using gene editing technology. Studies have shown that Mpo KO mice exhibit almost no physiological abnormalities under normal conditions and are only more susceptible to certain pathogen infections. In ANCA-associated vasculitis (AAV) studies, Mpo KO mice are widely used to prepare mouse auto-MPO antibodies. The specific method involves immunizing Mpo KO mice with recombinant mouse MPO antigen as donors to produce anti-mouse MPO auto-antibodies, and then injecting the antibodies into normal mice (or target humanized mice) to induce ANCA-associated vasculitis and use them for targeted drug testing. This method is the most commonly used approach in ANCA research. It has been applied to the preclinical efficacy testing of avacopan, a C5aR antagonist approved by the FDA for the treatment of ANCA.
Application Area
Studies on neutrophil function and anti-bacterial and anti-fungal infections
Preparation of anti-mouse MPO auto-antibodies
Studies on anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)
Validation Data