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NKG-SGM3
Product ID:
I001177
Background:
NKG
Documents:
Click here to download >
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Basic Information
Model Name
NKG-SGM3
Product ID
I001177
Gene Name
Il2rg, IL3, CSF2, KITLG
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); IL-3; MCGF; MULTI-CSF; CSF; GMCSF; SF; MGF; SCF; SLF; DCUA; FPH2; FPHH; KL-1; Kitl; WS2F; SHEP7; DFNA69
Classification
Immunodeficient Mouse Models
NCBI ID
16186, 3562, 1437, 4254
Phenotype
MGI:96551, MGI:96552, MGI:1339752, MGI:96974
Chromosome
X
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Document
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Note
Note: When using this mouse strain in a publication, please cite “NKG-SGM3 mice (Catalog I001177) were purchased from Cyagen.”
Strain Description
NKG-SGM3 mice constructed by integrating human KITLG, CSF2, and IL3 genes into the genome of NKG mice can effectively enhance myeloid differentiation and improve the transplantation efficiency of hematopoietic and acute myeloid leukemia cells and thus are valuable for immuno-oncology, immunology, and infectious disease research.
Application Area
Area
Construction of an immune system humanized mouse model supporting stable engraftment of myeloid lineages and regulatory T cell populations
Area
Research on the human immune system, hematopoietic systems, such as acute myeloid leukemia (AML)
Area
Human-derived cell line xenograft (CDX) and patient-derived xenograft (PDX)
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