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B6-hGLP-1R/ob
Product ID:
C001601
Background:
C57BL/6NCya;C57BL/6JCya
Documents:
Click here to download >
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Basic Information
Model Name
B6-hGLP-1R/ob
Product ID
C001601
Gene Name
GLP1R, Lep
Background
C57BL/6NCya;C57BL/6JCya
Gene Alias
GLP-1; GLP-1R; GLP-1-R; ob; obese
Classification
Metabolic Target Humanized Models,Metabolic Disease Models
NCBI ID
2740, 16846
Phenotype
MGI:99571, MGI:104663
Chromosome
6
More
Rare Disease Data Center >>
Document
Click here to download >>
Note
Note: When using this mouse strain in a publication, please cite “B6-hGLP-1R/ob mice (Catalog C001601) were purchased from Cyagen.”
Strain Description
The B6-hGLP-1R/ob mouse model, generated by mating B6-hGLP-1R mice (Catalog Number: C001421) with Lep KO (ob/ob) mice (Catalog Number: C001368), is a metabolic disease model. It can be used for research on the pathogenic mechanisms of various metabolic diseases, such as obesity and type II diabetes, and for screening GLP-1RA drugs.
Application Area
Area
Investigation of the pathogenesis of obesity and type 2 diabetes
Area
Development and screening of drugs for obesity and type 2 diabetes
Area
Research on other metabolic diseases such as cardiovascular and myocardial diseases
Area
Study of the neuroprotective effect in nervous system diseases
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