FVB-Abcb4 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
FVB-Abcb4 KO
Product ID
C001590
Gene Name
Background
FVB/NJCya
Gene Alias
Mdr2; Pgy2; Pgy-2; mdr-2
Classification
Metabolic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
5
Document
Note: When using this mouse strain in a publication, please cite “FVB-Abcb4 KO mice (Catalog C001590) were purchased from Cyagen.”
Strain Description
Cyagen has generated the FVB-Abcb4 KO mouse model by knocking out the Abcb4 gene in FVB mice. This model lacks the Abcb4 gene and protein expression and exhibits liver enlargement, elevated liver function markers, and increased total bilirubin. Histopathological examination shows hepatocyte necrosis, inflammatory cell infiltration, connective tissue proliferation, bile duct proliferation, and liver fibrosis.
Application Area
Study of Multidrug Resistance Protein 3 (MDR3) function
Mechanistic studies of Progressive Familial Intrahepatic Cholestasis Type 3 (PFIC3)
Drug development, screening, and preclinical efficacy evaluation for PFIC3 treatment
Validation Data