FVB-Abcb4 KO
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Strain Description
Cyagen has generated the FVB-Abcb4 KO mouse model by knocking out the Abcb4 gene in FVB mice. This model lacks the Abcb4 gene and protein expression and exhibits liver enlargement, elevated liver function markers, and increased total bilirubin. Histopathological examination shows hepatocyte necrosis, inflammatory cell infiltration, connective tissue proliferation, bile duct proliferation, and liver fibrosis.
Application Area
Study of Multidrug Resistance Protein 3 (MDR3) function
Mechanistic studies of Progressive Familial Intrahepatic Cholestasis Type 3 (PFIC3)
Drug development, screening, and preclinical efficacy evaluation for PFIC3 treatment
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