Gcdh KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Gcdh KO
Product ID
C001594
Gene Name
Background
C57BL/6JCya
Gene Alias
GCD; 9030411L18
Classification
Metabolic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
8
Document
Note: When using this mouse strain in a publication, please cite “Gcdh KO mice (Catalog C001594) were purchased from Cyagen.”
Strain Description
This strain was developed by gene editing to knock out the mouse Gcdh gene (the homolog of human GCDH), resulting in significantly elevated GA levels in plasma, brain, and liver tissues. It recapitulates the typical biochemical features of GA1 and is an ideal model for studying GA1 pathogenesis, drug development, and GCDH function.
Application Area
Functional studies of GCDH protein
Investigation of GA1 pathogenesis
Development, screening, and preclinical evaluation of therapeutic drugs for GA1
Validation Data