B6-hCFTR*F508del
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Age
Genotype
Sex
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Basic Information
Model Name
B6-hCFTR*F508del
Product ID
I001226
Gene Name
Background
C57BL/6NCya
Gene Alias
CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1
Classification
Full-Gene Humanized Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
7
Document
Note: When using this mouse strain in a publication, please cite “B6-hCFTR*F508del mice (Catalog I001226) were purchased from Cyagen.”
Strain Description
This strain was developed by introducing the F508del mutation into the CFTR-humanized mouse model (Catalog Number: I001132), creating a humanized disease model. The introduction of the mutation results in the manifestation of CF-related phenotypes in mice, making it suitable for research into CF mechanisms and the screening, development, and evaluation of therapies targeting the CFTR F508del mutation.
Application Area
Research on Cystic Fibrosis (CF)
Validation Data