B6-hIL23A/hIL12B
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Genotype
Sex
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Basic Information
Model Name
B6-hIL23A/hIL12B
Product ID
C001620
Background
C57BL/6NCya
Gene Alias
P19; SGRF; IL-23; IL-23A; IL23P19; CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
Phenotype
Chromosome
12
Document
Note: When using this mouse strain in a publication, please cite “B6-hIL23A/hIL12B mice (Catalog C001620) were purchased from Cyagen.”
Strain Description
B6-hIL23A&hIL12B mice are IL12B and IL23A double humanized mouse models obtained by mating IL12B humanized mouse models with IL23A humanized mouse models. They express human IL12B and IL23A genomic sequences under the control of mouse promoters. This model is capable of reproducing human IL-23 cytokines and is a valuable tool for studying immune-related diseases. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting IL-23 cytokines.
Application Area
IL23A/IL12B-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of immune-related diseases
Validation Data