B6-hTFRC/htau*P301L
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Genotype
Sex
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Basic Information
Model Name
B6-hTFRC/htau*P301L
Product ID
C001687
Background
C57BL/6N;6JCya
Gene Alias
TAU; FTD1; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6; T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
Classification
Full-Gene Humanized Models,Neurological Disease Models,Rare Disease Models
Chromosome
17
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Note: When using this mouse strain in a publication, please cite “B6-hTFRC/htau*P301L mice (Catalog C001687) were purchased from Cyagen.”
Strain Description
The B6-hTFRC/htau*P301L mouse model is a humanized model obtained by breeding B6-hTFRC(CDS) mice (Catalog No.: C001584) with B6-htau*P301L mice (Catalog No.: I001181). This model can be used for research on Alzheimer's disease (AD), Frontotemporal dementia (FTD), neurodegenerative diseases, and tumor development, aiding in the research of TFRC/MAPT-targeted drugs.
Application Area
Research on Alzheimer's disease (AD), Frontotemporal dementia (FTD), neurodegenerative diseases, and tumor development
Development, screening, and efficacy evaluation of TFRC/MAPT-targeted therapies
Research and evaluation of drug delivery across the blood-brain barrier (BBB)
Validation Data