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B6-hTFRC/htau*P301L
Product ID:
C001687
Background:
C57BL/6N;6JCya
Documents:
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Basic Information
Model Name
B6-hTFRC/htau*P301L
Product ID
C001687
Gene Name
MAPT, TFRC
Background
C57BL/6N;6JCya
Gene Alias
TAU; FTD1; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6; T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
Classification
Full-Gene Humanized Models,Neurological Disease Models,Rare Disease Models
NCBI ID
4137, 7037
Phenotype
MGI:97180, MGI:98822
Chromosome
17
More
Rare Disease Data Center >>
Document
Click here to download >>
Note
Note: When using this mouse strain in a publication, please cite “B6-hTFRC/htau*P301L mice (Catalog C001687) were purchased from Cyagen.”
Strain Description
The B6-hTFRC/htau*P301L mouse model is a humanized model obtained by breeding B6-hTFRC(CDS) mice (Catalog No.: C001584) with B6-htau*P301L mice (Catalog No.: I001181). This model can be used for research on Alzheimer's disease (AD), Frontotemporal dementia (FTD), neurodegenerative diseases, and tumor development, aiding in the research of TFRC/MAPT-targeted drugs.
Application Area
Area
Research on Alzheimer's disease (AD), Frontotemporal dementia (FTD), neurodegenerative diseases, and tumor development
Area
Development, screening, and efficacy evaluation of TFRC/MAPT-targeted therapies
Area
Research and evaluation of drug delivery across the blood-brain barrier (BBB)
Validation Data
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