B6-hIL4/hIL4RA
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIL4/hIL4RA
Product ID
C001834
Background
C57BL/6NCya
Gene Alias
BSF1; IL-4; BCGF1; BSF-1; BCGF-1; CD124; IL4RA; IL-4RA
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hIL4/hIL4RA mice (Catalog C001834) were purchased from Cyagen.”
Strain Description
The B6-hIL4/hIL4RA mouse model is generated by crossing IL4 humanized mice (Catalog Number: C001628) with IL4R humanized mice (Catalog Number: C001629), resulting in a dual-humanized model. This model faithfully recapitulates the human IL-4/IL-4R signaling pathway, making it an invaluable tool for studying allergic diseases (e.g., asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Furthermore, it serves as a robust preclinical platform for evaluating the efficacy and mechanisms of therapeutic agents targeting the IL-4/IL-4Rα pathway.
Application Area
Investigation of immune regulation and Th2 responses, allergic diseases, parasitic infections, and tumor immunology
Preclinical development, screening, and efficacy evaluation of IL4/IL4R-targeted therapeutic agents
Studies on inflammation and autoimmune diseases
Validation Data