B6-hRHO (Promoter)/hRHO*P23H (Promoter)
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Basic Information
Model Name
B6-hRHO (Promoter)/hRHO*P23H (Promoter)
Product ID
C001839
Gene Name
Background
C57BL/6JCya
Gene Alias
RP4; OPN2; CSNBAD1
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
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Datasheet
Note: When using this mouse strain in a publication, please cite “B6-hRHO (Promoter)/hRHO*P23H (Promoter) mice (Catalog C001839) were purchased from Cyagen.”
Strain Description
B6-hRHO (Promoter) /hRHO*P23H (Promoter) mouse is an F1 humanized model generated by crossing homozygous B6-hRHO (Promoter) mice (Catalog No.: C001646) with homozygous B6-hRHO*P23H (Promoter) mice (Catalog No.: C001727). This model carries two human RHO gene alleles, both with humanized promoter regions. One allele is the wild-type human RHO (without mutation), while the other is the human RHO carrying a pathogenic point mutation (P23H) (hRHO*P23H). The abnormal proteins encoded by the human genes are expressed in mice, resulting in abnormal retinal morphology, functional impairments, and visual defects in this model. Additionally, leveraging the technological innovation of independently developed TurboKnockout-fused BAC recombination, Cyagen Biosciences can provide customized services for different point mutations based on B6-hRHO humanized mice to meet the experimental needs of researchers, such as pharmacodynamic studies related to retinitis pigmentosa (RP).
Application Area
Research on retinitis pigmentosa (RP)
Research on congenital stationary night blindness (CSNB)
Research on other retinal diseases
Validation Data