B6-huUSH2A*c.2299delG
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Basic Information
Model Name
B6-huUSH2A*c.2299delG
Product ID
C001850
Gene Name
Background
C57BL/6JCya
Gene Alias
US2; RP39; USH2; dJ1111A8.1
Classification
Full-Gene Humanized Models,Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huUSH2A*c.2299delG mice (Catalog C001850) were purchased from Cyagen.”
Strain Description
B6-huUSH2A*c.2299delG mice are obtained by introducing the c.2299delG mutation into the exon 13 of the human USH2A gene in B6-hUSH2A (E10-15) mice (Catalog Number: C001554) using gene editing technology. This model can be used to study the mechanisms and therapeutic approaches for diseases such as Usher syndrome Type II.
Application Area
Investigation of the pathogenic mechanisms underlying Usher syndrome (USH) and preclinical evaluation of therapeutic drugs
Development, screening, and preclinical evaluation of drugs targeting USH2A
Validation Data